AI Article Synopsis
- The study investigated the effects of fruit of (FNT) on the health of sheep, specifically looking at six Hu rams and their response to varying levels of FNT intake (0, 16, and 48 g/d).
- Results showed that higher FNT consumption led to increased levels of serum immunoglobulin G, which is linked to improved immunity, and lower β-hydroxybutyrate levels compared to the control group.
- Additionally, FNT intake positively influenced the abundance of beneficial ruminal bacteria, suggesting it could enhance overall sheep health.
Article Abstract
The fruit of (FNT) is reputed to possess medicinal properties; however, its effect on sheep () is unknown. The aim of this study was to fill this gap. In a 3 × 3 Latin square design, six 12-month-old rumen-fistulated Hu rams (56.2 ± 8.26 kg; mean ± SD) were penned individually and offered one of three levels of FNT, namely, 0 g/d (control; CON), 16 g/d (N), and 48 g/d (N). The concentration of serum immunoglobulin G increased linearly ( = 0.03) with an increasing intake of FNT. The serum concentration of β-hydroxybutyrate in the N group was lower than in the CON group ( = 0.01) and decreased linearly with increasing FNT ( = 0.001). The concentration of serum lactate dehydrogenase tended to decrease ( = 0.07) linearly with an increase in FNT intake, while the concentration of glucose did not differ among groups ( = 0.14) but displayed a quadratic curve with an increase in FNT ( = 0.05). The rumen concentration of lipase decreased linearly with increasing FNT ( = 0.04). The rumen fermentation variables were not affected by FNT. The FNT intake increased the abundance of beneficial ruminal bacteria, such as , Rhodocyclaceae, and Arthromitus. , ___, , , __, and were the dominant bacterial genera in all treatments. We conclude that FNT can improve immunity and increase the relative abundance of beneficial ruminal bacteria in sheep.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9686964 | PMC |
| http://dx.doi.org/10.3390/ani12223211 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Air pollution modifies colonisation factors in beneficial symbiont Snodgrassella and disrupts the bumblebee gut microbiome.
NPJ Biofilms Microbiomes
January 2025
Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
Particulate air pollutants, a major air pollution component, are detrimental to human health and a significant risk to wildlife and ecosystems globally. Here we report the effects of particulate pollutant black carbon on the beneficial gut microbiome of important global insect pollinator, the buff-tailed bumblebee (Bombus terrestris). Our data shows that exposure to black carbon particulates alters biofilm structure, gene expression and initial adhesion of beneficial bee gut coloniser, Snodgrassella alvi.
View Article and Find Full Text PDFDual GIP and GLP-1 receptor agonist tirzepatide alleviates hepatic steatosis and modulates gut microbiota and bile acid metabolism in diabetic mice.
Int Immunopharmacol
January 2025
Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan 030000, China. Electronic address:
Tirzepatide is a dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors and is a promising therapeutic option for type 2 diabetes mellitus (T2DM). Nevertheless, its effect and underlying mechanism on hepatic steatosis remain ambiguous. Herein, we explored the impact of tirzepatide on improving hepatic steatosis in diabetic mice, with a particular focus on the gut microbiota and bile acids (BAs) using animal models.
View Article and Find Full Text PDFTertiary lymphoid structures in high-grade serous tubo-ovarian carcinoma: anatomical site matters.
Cancer Immunol Immunother
January 2025
Division of Oncology, Department of Clinical Sciences Lund, and Lund University Cancer Center, Lund University, Lund, Sweden.
Tertiary lymphoid structures (TLS) in the tumor microenvironment are prognostically beneficial in many solid cancer types. Reports on TLS in high-grade serous tubo-ovarian carcinoma (HGSC) are few, and the prognostic impact is unclear. We investigated mature TLS (mTLS), immature TLS (iTLS) and lymphoid aggregates (LA) in primary adnexal tumors (PTs) and synchronous omental/peritoneal metastases (pMets) of HGSC.
View Article and Find Full Text PDFBackground: The efficacy of Calorie Restriction (CR) in enhancing cognition, promoting healthy aging, and extending lifespan is well-established. Yet, it remains unclear whether the apolipoprotein E (APOE) genotype, a known modifier for aging and age-related disorders, influences the beneficial effects of CR in countering aging.
Methods: To investigate this question, we utilized humanized APOE mouse models, which express APOE2, APOE3, or APOE4 alleles systematically (refer to as E2, E3, and E4 mice).
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of California, San Diego, La Jolla, CA, USA.
Background: Studies using Alzheimer's disease (AD) models suggest that gut bacteria contribute to amyloid pathology and systemic inflammation. Further, gut-derived metabolites serve critical roles in regulating cholesterol, blood-brain barrier permeability, neuroinflammation, and circadian rhythms. Recent studies from the Alzheimer's Disease Neuroimaging Initiative have shown that serum-based gut-derived metabolites are associated with AD biomarkers and cognitive impairment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!