AI Article Synopsis
- Glycozolidol (GLD), derived from a specific root, shows promising antioxidant properties that could be linked to its ability to scavenge radicals, though this aspect hasn't been thoroughly studied before.
- The research utilized Density Functional Theory (DFT) calculations to assess GLD's effectiveness against various significant radicals in biological conditions, finding it exhibits substantial antiradical activity in both water and lipid-like environments.
- The mechanisms of this activity differ by solvent, with proton-loss electron transfer being predominant in water and hydrogen transfer in nonpolar solvents, indicating that GLD could be a potent radical scavenger in physiological settings.
Article Abstract
Glycozolidol was isolated from the root of (6-hydroxy-2-methoxy-3-methylcarbazole, GLD). This molecule attracted considerable interest due to its beneficial biological activities that likely stem from its antioxidant activity; yet, the radical scavenging action of GLD has not been investigated thus far. In this study, DFT calculations were used to estimate the radical scavenging activity of GLD against a variety of biologically significant radical species in physiological environments. The findings demonstrated that GLD exerts significant antiradical activity in water at pH = 7.40 and in pentyl ethanoate (as a model of lipidic media) with = 8.23 × 10 and 3.53 × 10 M s, respectively. In aqueous solution, the sequential proton-loss electron transfer mechanism made the highest contribution to the activity, whereas in nonpolar solvents the formal hydrogen transfer mechanism dominated the activity. GLD is predicted to have strong antiradical activity against CHO˙, CHOO˙, CClOO˙, NO, SO˙, DPPH and ABTS˙ ≈ 10 M s and ≈ 10 M s. The results suggest that GLD is a good radical scavenger in physiological environments.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9671143 | PMC |
| http://dx.doi.org/10.1039/d2ra05907j | DOI Listing |
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