Biphasic calcium phosphate (BCP) is generally considered a good synthetic bone graft material with osteoinductive potential. Lithium ions are trace elements that play a role in the bone-remodeling process. This study aimed to investigate the effects of lithium ions on the phase, crystal structure, and biological responses of lithium doped BCPs and to identify improvements in their osteogenic properties. Lithium-doped BCP powders with different doping levels (0, 5, 10, and 20 at%) were synthesized the co-precipitation method. We found that the four types of lithium-doped BCP powders showed different phase compositions of hydroxyapatite and β-tricalcium phosphate. In addition, lithium ions favored entering the β-tricalcium phosphate structure at the Ca (4) sites and calcium vacancy sites [V(4)] up to 10 at%. This substitution improves the crystal stabilization by filling the vacancies with Ca and Li in all Ca sites. However, when the concentration of Li ions was higher than 10 at%, lithium-induced crystal instability resulted in the burst release of lithium ions, and the osteogenic behavior of human dental pulp stem cells did not improve further. Although lithium ions regulate osteogenic properties, it is important to determine the optimal amount of lithium in BCPs. In this study, the most effective lithium doping level in BCP was approximately 10 at% to improve its biological properties and facilitate medical applications.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9679216 | PMC |
| http://dx.doi.org/10.3389/fbioe.2022.993126 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Contribution of Nuclear Fragmentation to Dose and RBE in Carbon-Ion Radiotherapy.
Radiat Res
January 2025
Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Variable relative biological effectiveness (RBE) of carbon radiotherapy may be calculated using several models, including the microdosimetric kinetic model (MKM), stochastic MKM (SMKM), repair-misrepair-fixation (RMF) model, and local effect model I (LEM), which have not been thoroughly compared. In this work, we compared how these four models handle carbon beam fragmentation, providing insight into where model differences arise. Monoenergetic and spread-out Bragg peak carbon beams incident on a water phantom were simulated using Monte Carlo.
View Article and Find Full Text PDFOptimal Blend Between Fluorinated Esters and Fluorinated Ether for High-Performance Lithium-Ion Cells at High Voltage.
Materials (Basel)
January 2025
College of Safety Science and Engineering, Nanjing Tech University, Nanjing 211816, China.
An experimental investigation is conducted to identify the optimal blend of fluoroethylene carbonate (FEC), 3,3,3-trifluoropropylene carbonate (TFEC), and various fluorinated ethers, including 1,1,2,2-tetrafluoroethyl-2,2,2-trifluoroethyl ether (HFE), 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether (TTE), and bis(2,2,2-trifluoroethyl) ether (BTE), to enhance the performances of lithium-ion cells at high voltage. The cell incorporating TTE exhibits a significantly superior capacity for retention after long-term cycling at 4.5 V, which might be attributed to the improved kinetics of lithium ions and the generation of a thin, reliable, and inorganic-rich electrode-electrolyte interface.
View Article and Find Full Text PDFPartially amorphous vanadium oxysulfide for achieving high-performance Li-ion batteries.
J Colloid Interface Sci
January 2025
College of Materials Science and Engineering, Nanjing Tech University, Nanjing 211816 China. Electronic address:
Vanadium-based materials exhibit a high theoretical capacity and diverse valence states, rendering them promising candidate anodes for lithium-ion batteries (LIBs). However, the cycling and rate performance are limited by their weak structural stability and electrical conductivity. Herein, a rational amorphization strategy has been developed to construct dual-anion vanadium oxysulfide nanoflowers (VSO NFs) with partial amorphous components and abundant oxygen vacancies as anode material for LIBs.
View Article and Find Full Text PDFIn situ formation of LiN interlayer enhancing interfacial stability of solid-state lithium batteries.
J Colloid Interface Sci
January 2025
School of Chemical & Environmental Engineering, China University of Mining and Technology-Beijing, Beijing 100083, PR China. Electronic address:
The uneven deposition of lithium ions has raised safety concerns related to the growth of lithium dendrites on the surface of lithium metal batteries. In this work, an in situ formed LiN interlayer is introduced to regulate the deposition of lithium ions on the lithium metal surface effectively. The LiN interlayer is formed on the lithium metal surface by the reaction of nitrogen gas (N) released from the reaction layer at a specific temperature.
View Article and Find Full Text PDFEnhancing osteogenic properties with gelatin/chitosan hydrogel encapsulating lithium-coated titanium oxide hollow sphere particles loaded with quercetin.
Biomed Mater
January 2025
Department of Emergency, Shandong University, Department of Emergency, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, PR China, Jinan, Shandong, 250100, CHINA.
Metallic oxides especially lithium and titanium oxides are well known for their osteogenic properties. When combined in the right proportions, metallic oxides can have an even greater impact. However, releasing ions from oxides can lead to oxidative stress, which is harmful to cell growth.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!