Potent antibacterial activity of MXene-functionalized graphene nanocomposites.

Two dimensional (2D) nanomaterials display properties with significant biological utility (, antimicrobial activity). In this study, MXene-functionalized graphene (FG) nanocomposites with TiCT in varying ratios (FG : TiCT , 25 : 75%, 50 : 50%, and 75 : 25%) were prepared and characterized scanning electron microscopy, scanning electron microscopy-energy dispersive X-ray (SEM-EDX), high-resolution transmission electron microscopy (HRTEM), and zeta potential analysis. Their cytotoxicity was assessed using immortalized human keratinocytes (HaCaT) cells at three different timepoints, and antibacterial activity was assessed using Gram-positive Methicillin resistant , MRSA, and Gram-negative neuro-pathogenic K1 ( K1) . The nanomaterials and composites displayed potent antibacterial effects against both types of bacteria and low cytotoxicity against HaCaT cells at 200 μg mL, which is promising for their utilization for biomedical applications.