Anticancer Agents Med Chem
Faculty of Biotechnology, MSA University, El Giza, Egypt.
Published: May 2023
The current study demonstrates amygdalin's (vitamin B17) postulated mechanism of action on cancer cells where it kills cells by selective toxicity, promotes apoptosis via cell cycle arrest, induces apoptosis via intrinsic cell death pathway (the mitochondria-initiated pathway), and enhances immunity. Thus, amygdalin can be considered a valuable natural cancer therapeutic agent. The toxicity of Amygdalin was reviewed. Moreover, solutions to avoid the cyanide poisoning have been proposed.
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http://dx.doi.org/10.2174/1871520623666221124143751 | DOI Listing |
J Exp Psychol Learn Mem Cogn
December 2024
Technical University of Darmstadt, Institute of Psychology.
The goal of the present investigation was to perform a registered replication of Jones and Macken's (1995b) study, which showed that the segregation of a sequence of sounds to distinct locations reduced the disruptive effect on serial recall. Thereby, it postulated an intriguing connection between auditory stream segregation and the cognitive mechanisms underlying the irrelevant speech effect. Specifically, it was found that a sequence of changing utterances was less disruptive in stereophonic presentation, allowing each auditory object (letters) to be allocated to a unique location (right ear, left ear, center), compared to when the same sounds were played monophonically.
View Article and Find Full Text PDFDrug Deliv
December 2025
College of Pharmacy, Xinxiang Medical University, Xinxiang, China.
Silicosis represents a formidable occupational lung pathology precipitated by the pulmonary assimilation of respirable crystalline silica particulates. This condition engenders a cascade of cellular oxidative stress via the activation of bioavailable silica, culminating in the generation of reactive oxygen species (ROS). Such oxidative mechanisms lead to irrevocable pulmonary impairment.
View Article and Find Full Text PDFJ Chromatogr A
January 2025
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608 Taiwan.
Despite having identical physicochemical properties, chiral molecules require effective separation techniques due to their distinct pharmacological effects. Polysaccharide-based chiral stationary phases (CSPs) are widely used for chiral separations in liquid chromatography; however, the mechanisms of chiral recognition are not well understood. This research explored the adsorption, retention, and chiral recognition mechanisms of three amylose-based CSPs: Chiralpak ID, IF, and IG.
View Article and Find Full Text PDFChemosphere
January 2025
DICAR University of Pavia, 27100 Pavia, Italy. Electronic address:
Excess biological sludge processing and disposal have a significant impact on the energy balance and economics of wastewater treatment operations, and on receiving environments. Anaerobic digestion is probably the most widespread in-plant sludge processing method globally, since it stabilizes and converts biosolids organic matter into biogas, allowing partial recovery of their embedded chemical energy. A considerable number of studies concerning applicable techniques to improve biogas production, both in quantity and quality, include pre-treatment strategies to promote biosolids disintegration aimed at the release and solubilisation of intracellular energy compounds, inorganic/biological amendments aimed at improving process performance, and sludge thermal pre-treatment.
View Article and Find Full Text PDFVet Parasitol
January 2025
Centro de Investigaciones Básicas y Aplicadas, Universidad Nacional del Noroeste de la Provincia de Buenos Aires, Junín, Buenos Aires 6000, Argentina; Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires, CITNOBA, UNNOBA - UNSAdA - CONICET, Monteagudo 2772, Pergamino, Buenos Aires 2700, Argentina. Electronic address:
Dairy heifers with gastrointestinal nematodes have reduced growth rates, and delayed age at puberty and milk production onset related to late mammary gland development. IGF1 and Notch signaling systems are important in this process, and an altered profile of serum IGF1 has been associated with the detrimental effect of the nematodes on parenchymal development. In this context, we aimed to study the molecular mechanisms involved in bovine mammary gland development around pre and postpuberty, focusing on proliferative and angiogenic processes that involve the Notch and IGF1 pathways.
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