Shock is a life-threatening condition of circulatory failure leading to inadequate organ perfusion and tissue oxygenation. In a trauma patient, shock may be due to hypovolemia, cardiogenic, obstructive or distributive causes individually or in combination. The physiological response to major hemorrhage is dependent on a variety of autonomic reflexes, mechanism of injury, bleeding source, and baseline physiology of the patient. This article discusses the common causes of shock and the accompanying physiology, how clinical assessment can support the diagnosis and effective treatment of shock, and the common pitfalls in trauma patients.
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http://dx.doi.org/10.1016/j.emc.2022.09.007 | DOI Listing |
Nano Lett
January 2025
Shenzhen Institute for Advanced Study, University of Electronic Science and Technology of China, Shenzhen 518110, China.
Efficient oxygen evolution reaction (OER) catalysts with fast kinetics, high efficiency, and stability are essential for scalable green production of hydrogen. The rational design and fabrication of catalysts play a decisive role in their catalytic behavior. This work presents a high-entropy catalyst, FeCoNiCuMo-O, synthesized via carbothermal shock.
View Article and Find Full Text PDFJ Virol
January 2025
Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tübingen, Tübingen, Germany.
One key determinant of HIV-1 latency reversal is the activation of the viral long terminal repeat (LTR) by cellular transcription factors such as NF-κB and AP-1. Interestingly, the activity of these two transcription factors can be modulated by glucocorticoid receptors (GRs). Furthermore, the HIV-1 genome contains multiple binding sites for GRs.
View Article and Find Full Text PDFJ Exp Zool A Ecol Integr Physiol
January 2025
Department of Biology, Widener University, Chester, Pennsylvania, USA.
Cold-water fishes, such as Brook trout (Salvelinus fontinalis), are being challenged by the consequences of climate change. The ability of these fish to acclimate to warmer environmental conditions is vital to their survival. Acclimation to warmer water may allow brook trout to reduce the metabolic costs of higher temperatures.
View Article and Find Full Text PDFASAIO J
January 2025
From the Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Mortality remains elevated during venoarterial extracorporeal membrane oxygenation support (VA-ECMO) for cardiogenic shock and the role of inflammation is uncertain. By using the neutrophil-to-lymphocyte ratio (NLR), we investigated inflammatory dynamics during VA-ECMO and their relation to clinical outcomes. A single-center, retrospective cohort study was conducted.
View Article and Find Full Text PDFJ Am Heart Assoc
January 2025
Monash Heart Victorian Heart Hospital, Monash Health Melbourne Australia.
Background: Preprocedural fasting is widely used before percutaneous coronary intervention (PCI). However, the incidence of procedural intubation during PCI is unknown. This study aims to identify the incidence and predictors for procedural intubation during PCI.
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