AI Article Synopsis
- The Barretos Cancer Hospital Animal Facility (BCHAF) in Brazil specializes in using animal models to advance cancer research.
- The facility conducts experiments involving mutant strains of mice, xenograft models, and patient-derived xenografts (PDXs).
- The research highlights both progress and challenges in creating these models to improve understanding of tumor biology and to identify potential cancer biomarkers for personalized treatment.
Article Abstract
The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9699001 | PMC |
| http://dx.doi.org/10.3390/vetsci9110636 | DOI Listing |
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