Inhibitory Effect of Select Nitrocompounds and Chlorate against and In Vitro.

is an important fish pathogen causing enteric redmouth disease. Antibiotics have traditionally been used to control this pathogen, but concerns of antibiotic resistance have created a need for alternative interventions. Presently, chlorate and certain nitrocompounds were tested against as well as a related species within the genus, , to assess the effects of these inhibitors. The results reveal that 9 mM chlorate had no inhibitory effect against , but inhibited growth rates and maximum optical densities of by 20-25% from those of untreated controls (0.46 h and 0.29 maximum optical density, respectively). The results further reveal that 2-nitropropanol and 2-nitroethanol (9 mM) eliminated the growth of both and during anaerobic or aerobic culture. Nitroethane, ethyl nitroacetate and ethyl-2-nitropropionate (9 mM) were less inhibitory when tested similarly. Results from a mixed culture of with fish tank microbes and of with porcine fecal microbes reveal that the anti- activity of the tested nitrocompounds was bactericidal, with 2-nitropropanol and 2-nitroethanol being more potent than the other tested nitrocompounds. The anti- activity observed with these tested compounds warrants further study to elucidate the mechanisms of action and strategies for their practical application.