Antigenic Proteins Shared with Acute Lymphoblastic Leukemia and Neuroblastoma.

Research studies indicate that immunization with protein extracts of , the protozoan parasite that causes Chagas disease, prevents the appearance of tumors in 60% of mice injected with the murine lung carcinoma tumor line. The molecular basis of this process is unknown, although the presence of specific antigens in tumor cells and on the surface of suggests an antiparasitic immune response, with an effective cross-reaction against cancer cells, hence the importance to identify the antigens involved and determine their potential as target cells in anticancer therapy. This study aimed to determine the presence of antigenic proteins of shared with acute lymphoblastic leukemia and neuroblastoma cells. To achieve this, polyclonal antibodies against were developed in rabbits, and reactivity was determined with protein extracts of acute lymphoblastic leukemia cells and neuroblastoma. The immunodetection of five different strains of against anti- polyclonal antibodies was also performed. The study allows the knowledge of the immunological interactions between cancer and parasites to be expanded and, therefore, contributes to the design of more and better projects that improve the therapeutic strategies applied in oncology.