Five undescribed polyketide derivatives, pestaloketides A-E (-), along with eleven known analogues (-), were isolated from the sponge-derived fungus sp. Their structures, including absolute configurations, were elucidated by analyses of NMR spectroscopic HRESIMS data and electronic circular dichroism (ECD) calculations. Compounds , , , and exhibited weak cytotoxicities against four human cancer cell lines, with IC values ranging from 22.1 to 100 μM. Pestaloketide A () is an unusual polyketide, featuring a rare 5/10/5-fused ring system. Pestaloketides A () and B () exhibited moderately inhibited LPS-induced NO production activity, with IC values of 23.6 and 14.5 μM, respectively, without cytotoxicity observed. Preliminary bioactivity evaluations and molecular docking analysis indicated that pestaloketides A () and B () had the potential to be developed into anti-inflammatory activity drug leads.
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| http://dx.doi.org/10.3390/md20110711 | DOI Listing |
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