AI Article Synopsis
- Photodynamic therapy (PDT) is a promising anticancer treatment but faces limitations like reactive oxygen species (ROS) quenching and short oxygen lifetimes, which reduce its effectiveness.
- Aggregation-induced emission luminogen (AIEgens)-based photosensitizers (PSs) enhance ROS generation, making them particularly useful for treating hypoxic tumors.
- This review outlines design strategies and applications of AIEgen-based PSs since 2019, categorizing them into organelle-targeting PSs and tumor-targeting PSs, while discussing current challenges and future opportunities in improving PDT efficacy.
Article Abstract
Photodynamic therapy (PDT) has attracted much attention in the field of anticancer treatment. However, PDT has to face challenges, such as aggregation caused by quenching of reactive oxygen species (ROS), and short O lifetime, which lead to unsatisfactory therapeutic effect. Aggregation-induced emission luminogen (AIEgens)-based photosensitizers (PSs) showed enhanced ROS generation upon aggregation, which showed great potential for hypoxic tumor treatment with enhanced PDT effect. In this review, we summarized the design strategies and applications of AIEgen-based PSs with improved PDT efficacy since 2019. Firstly, we introduce the research background and some basic knowledge in the related field. Secondly, the recent approaches of AIEgen-based PSs for enhanced PDT are summarized in two categories: (1) organelle-targeting PSs that could cause direct damage to organelles to enhance PDT effects, and (2) PSs with tumor-targeting abilities to selectively suppress tumor growth and reduce side effects. Finally, current challenges and future opportunities are discussed. We hope this review can offer new insights and inspirations for the development of AIEgen-based PSs for better PDT effect.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9688568 | PMC |
| http://dx.doi.org/10.3390/bios12111027 | DOI Listing |
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Article Synopsis
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- Aggregation-induced emission luminogen (AIEgens)-based photosensitizers (PSs) enhance ROS generation, making them particularly useful for treating hypoxic tumors.
- This review outlines design strategies and applications of AIEgen-based PSs since 2019, categorizing them into organelle-targeting PSs and tumor-targeting PSs, while discussing current challenges and future opportunities in improving PDT efficacy.
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