AI Article Synopsis
- - Tissue engineering is advancing the creation of artificial human cardiac muscle patches (hCMPs) to help treat Myocardial infarction (MI) by enhancing heart regeneration.
- - Challenges such as low engraftment rates, scalability issues for clinical use, and the need for a functional vascular system hinder hCMP's practical implementation.
- - The paper explores various heart cell types for hCMP production, innovative engineering methods, and the significance of cell injection/transplantation in cardiac tissue engineering.
Article Abstract
Tissue engineering has paved the way for the development of artificial human cardiac muscle patches (hCMPs) and cardiac tissue analogs, especially for treating Myocardial infarction (MI), often by increasing its regenerative abilities. Low engraftment rates, insufficient clinical application scalability, and the creation of a functional vascular system remain obstacles to hCMP implementation in clinical settings. This paper will address some of these challenges, present a broad variety of heart cell types and sources that can be applied to hCMP biomanufacturing, and describe some new innovative methods for engineering such treatments. It is also important to note the injection/transplantation of cells in cardiac tissue engineering.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9687338 | PMC |
| http://dx.doi.org/10.3390/bioengineering9110696 | DOI Listing |
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