A novel chemerin receptor 1 (Chemerin) takes part in the immune response of cobia ().

Fish Shellfish Immunol Rep

Innovative Institute of Animal Healthy breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510222, Guangdong, China.

Published: December 2022

Chemerin receptor 1 (Chemerin) plays a critical role in innate and adaptive immune systems. In this study, a cobia () Chemerin was identified, and its molecular characterization and expression patterns were analyzed. Multiple sequence alignment revealed that the Chemerin possessed a typical dynein regulatory complex (DRC) motif. There was also a potential N-glycosylation site in the extracellular regions of the N-terminus and intracellular loops (ICL) 1 region. Phylogenetic analysis demonstrated that the Chemerin was clustered together with homologous proteins from other fish species. Chemerin was constitutively expressed in a wide range of tissues (especially in immune-related tissues) with different expression levels, which suggests that the Chemerin plays different roles in un-stimulated tissues. expression showed up-regulation in the head kidney after challenge. Up-regulation in the head kidney and spleen was also observed after polyinosinic-polycytidylic acid (poly I: C) challenge, which suggests that Chemerin may play vital roles during bacterial and viral infection. The differential responses of immune organs to bacteria and poly I: C imply the differences in defense mechanisms against viruses and bacteria.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680076PMC
http://dx.doi.org/10.1016/j.fsirep.2022.100057DOI Listing

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