Chemerin receptor 1 (Chemerin) plays a critical role in innate and adaptive immune systems. In this study, a cobia () Chemerin was identified, and its molecular characterization and expression patterns were analyzed. Multiple sequence alignment revealed that the Chemerin possessed a typical dynein regulatory complex (DRC) motif. There was also a potential N-glycosylation site in the extracellular regions of the N-terminus and intracellular loops (ICL) 1 region. Phylogenetic analysis demonstrated that the Chemerin was clustered together with homologous proteins from other fish species. Chemerin was constitutively expressed in a wide range of tissues (especially in immune-related tissues) with different expression levels, which suggests that the Chemerin plays different roles in un-stimulated tissues. expression showed up-regulation in the head kidney after challenge. Up-regulation in the head kidney and spleen was also observed after polyinosinic-polycytidylic acid (poly I: C) challenge, which suggests that Chemerin may play vital roles during bacterial and viral infection. The differential responses of immune organs to bacteria and poly I: C imply the differences in defense mechanisms against viruses and bacteria.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9680076 | PMC |
http://dx.doi.org/10.1016/j.fsirep.2022.100057 | DOI Listing |
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