AI Article Synopsis
- Researchers explored the relationship between naïve T cell homeostasis and aging, finding it poorly understood in humans.
- They developed a lymphoid organoid system that preserves resting naïve T cells for over two weeks while maintaining high CD45RA expression.
- Their findings indicate that aging leads to reduced CD45RA density in naïve T cells, potentially due to external factors in the lymph node environment affecting cell phenotype in older adults.
Article Abstract
A breakdown in cellular homeostasis is thought to drive naïve T cell aging, however the link between naïve T cell homeostasis and aging in humans is poorly understood. To better address this, we developed a lymphoid organoid system that maintains resting naïve T cells for more than 2 weeks, in conjunction with high CD45RA expression. Deep phenotypic characterization of naïve T cells across age identified reduced CD45RA density as a hallmark of aging. A conversion from CD45RA naive cells to a CD45RA phenotype was reproduced within our organoid system by structural breakdown, but not by stromal cell aging or reduced lymphocyte density, and mediated by alternative CD45 splicing. Together, these data suggest that external influences within the lymph node microenvironment may cause phenotypic conversion of naïve T cells in older adults.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9676450 | PMC |
| http://dx.doi.org/10.3389/fragi.2022.1045648 | DOI Listing |
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