Background: Cytomegalovirus (CMV) infection is a leading cause of morbidity and mortality after transplantation. This study aimed to investigate CMV seroprevalence, infection, and disease in Chinese thoracic organ transplant recipients.
Methods: The clinical data of the patients who underwent lung and/or heart transplantation between January 2015 and October 2020 were retrospectively collected from four transplantation centers in China.
Results: A total of 308 patients were analyzed. The CMV serostatus was donor positive (D) recipient negative (R) in 19 (6.17%) patients, D/R in 233 (75.65%), D/R in 36 (11.69%), and D/R in 20 (6.50%). CMV DNAemia was detected in 52.3% of the patients and tissue-invasive CMV disease was diagnosed in 16.2% of the patients. Only 31.8% of the patients adhered to the postdischarge valganciclovir therapy. The D/R serostatus (odds ratio [OR]: 18.32; 95% confidence interval [CI]:1.80-188.68), no valganciclovir prophylaxis (OR: 2.64; 95% CI: 1.05-6.64), and higher doses of rabbit anti-human thymocyte globulin (> 2 mg/kg) (OR: 4.25; 95% CI: 1.92-9.42) were risk factors of CMV disease.
Conclusion: CMV seroprevalence was high in Chinese thoracic organ transplant donors and recipients. The low adherence rate to the postdischarge CMV prophylaxis therapy in Chinese patients is still an unresolved issue.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9682642 | PMC |
| http://dx.doi.org/10.1186/s12879-022-07853-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
SNHG16 alleviates pulmonary ischemia-reperfusion injury by promoting the warburg effect through regulating MTCH2 expression: experimental studies.
Int J Surg
January 2025
Department of thoracic and cardiovascular surgery, Huashan Hospital, Affiliated with Fudan University, Shanghai, China.
Background: Pulmonary ischemia-reperfusion injury (PIRI) is a major cause of fatality post-lung transplantation. Though some long non-coding RNAs (lncRNAs) have been studied in acute lung injury (ALI), their effects on PIRI remain undefined. The present study aims to explore the underlying mechanism of small nucleolar RNA host gene 16 (SNHG16) in PIRI.
View Article and Find Full Text PDFImpact of PM, relative humidity, and temperature on sleep quality: a cross-sectional study in Taipei.
Ann Med
December 2025
School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Introduction: TWe investigated impacts of particulate matter with an aerodynamic diameter of less than 2.5 μm (PM), relative humidity (RH), and temperature on sleep stages and arousal.
Materials And Methods: A cross-sectional analysis involving 8,611 participants was conducted at a sleep center in Taipei.
Navigating the landscape of neoadjuvant immunotherapy for NSCLC: progress and controversies.
Ther Adv Med Oncol
January 2025
Department of Oncology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, No. 9 Beiguan Street, Tongzhou District, Beijing 101149, China.
Recently, attention has increasingly centered on non-small-cell lung cancer (NSCLC) with immune checkpoint inhibitors application. Numerous clinical studies have underscored the potential of immunotherapy in treating resectable NSCLC, highlighting its role in improving patient outcomes. However, despite these promising results, there is ongoing debate regarding the efficacy of immunological combination therapy strategies, the prevalence of treatment-related side effects, the identification of predictive biomarkers, and various other challenges within the neoadjuvant context.
View Article and Find Full Text PDFLymph Node Metastasis for pN+ Superficial Esophageal Squamous Cell Carcinoma.
Thorac Cancer
January 2025
Department of Thoracic Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of MedicalSciences and Peking Union Medical College, Beijing, China.
Objectives: This study aimed to analyze lymph node metastasis (LNM) distribution in superficial esophageal squamous cell carcinoma (ESCC) and its impact factors on survival.
Methods: We reviewed 241 pT1N+ ESCC cases between February 2012 and April 2022 from 10 Chinese hospitals with a high volume of esophageal cancer (EC). We analyzed clinicopathological data to identify overall survival (OS) risk factors and LNM distribution in relation to tumor invasion depth.
Fluorescent Heterocyclic Compound-Loaded BiSe-Polysorbate Nanoparticles for Targeted Therapy in Non-Small Cell Lung Cancer.
J Fluoresc
January 2025
Deparment of Hepatobiliary Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
This study introduces a novel approach for non-small cell lung cancer (NSCLC) treatment by developing BiSe-Polysorbate nanoparticles as a multifunctional platform for photothermal therapy and targeted drug delivery. The BiSe-Polysorbates nanoparticles are engineered as innovative photosensitive drug carriers, enhancing biocompatibility through the combination of BiSe and Polysorbates. Characterization techniques such as Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and ultraviolet-visible (UV-Vis) spectroscopy confirm the successful synthesis of the nanoparticles.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!