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Hormone therapies in meningioma-where are we? | LitMetric

Hormone therapies in meningioma-where are we?

J Neurooncol

Department of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.

Published: January 2023

AI Article Synopsis

  • Meningiomas are brain tumors linked to hormonal risk factors, primarily affecting females, and their growth is associated with hormone receptors like progesterone and somatostatin.
  • A literature review and analysis of clinical trials revealed that most steroid hormone trials did not consistently identify receptor status among patients, while studies involving somatostatin analogs often included positive receptor status.
  • The authors suggest that further research is needed to evaluate the effectiveness of hormonal therapies, emphasizing the importance of patient stratification based on tumor characteristics for future clinical trials.

Article Abstract

Introduction: Meningiomas are associated with several gonadal steroid hormone-related risk factors and demonstrate a predominance in females. These associations led to investigations of the role that hormones may have on meningioma growth and development. While it is now accepted that most meningiomas express progesterone and somatostatin receptors, the conclusion for other receptors has been less definitive.

Methods: We performed a review of what is known regarding the relationship between hormones and meningiomas in the published literature. Furthermore, we reviewed clinical trials related to hormonal agents in meningiomas using MEDLINE PubMed, Scopus, and the NIH clinical trials database.

Results: We identify that all steroid-hormone trials lacked receptor identification or positive receptor status in the majority of patients. In contrast, four out of five studies involving somatostatin analogs used positive receptor status as part of the inclusion criteria.

Conclusions: Several clinical trials have recently been completed or are now underway using somatostatin analogs in combination with other therapies that appear promising, but a reevaluation of hormone-based monotherapy is warranted. Synthesizing this evidence, we clarify the remaining questions and present future directions for the study of the biological role and therapeutic potential of hormones in meningioma and discuss how the stratification of patients using features such as grade, receptor status, and somatic mutations, might be used for future trials to select patients most likely to benefit from specific therapies.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10371392PMC
http://dx.doi.org/10.1007/s11060-022-04187-1DOI Listing

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