AI Article Synopsis
- The study focused on urinary liver-type fatty acid-binding protein (uL-FABP) as a potential early biomarker for chronic kidney disease (CKD) in healthy elderly cats, examining its levels in relation to CKD stages and proteinuria.
- In a sample of 196 healthy cats aged 7 and older, only 6 (3%) showed detectable uL-FABP levels, with none of the cats showing signs of IRIS stage 1 CKD having detectable levels, indicating low prevalence.
- The findings suggest that uL-FABP has limited effectiveness as a screening tool for detecting early CKD in cats, as it was rarely found in clinically healthy elderly cats,
Article Abstract
Background: Urinary liver-type fatty acid-binding protein (uL-FABP) is a promising biomarker to detect early chronic kidney disease (CKD) in cats. Few healthy cats show increased uL-FABP for unknown reasons.
Objectives: The objective of this study was to evaluate uL-FABP in a large healthy elderly cat population comparing cats with and without International Renal Interest Society (IRIS) stage 1 CKD and with and without borderline proteinuria.
Methods: This was a cross-sectional study. One hundred ninety-six clinically healthy client-owned cats of ≥7 years old were subdivided based on two criteria: (1) having either IRIS stage 1 CKD or no evidence of CKD and (2) having borderline proteinuria or no proteinuria. Urinary L-FABP was measured using a validated commercially available feline L-FABP ELISA.
Results: Overall, uL-FABP was detectable in 6/196 (3%) healthy elderly cats. For the first subdivision, nine (5%) cats had IRIS stage 1 CKD, 184 cats had no evidence CKD and three cats were excluded. All cats with IRIS stage 1 CKD had uL-FABP concentrations below the detection limit, whereas 6/184 (3%) cats without IRIS stage 1 CKD had detectable uL-FABP concentrations (median 1.79 ng/ml, range 0.79-3.66 ng/ml). For the second subdivision, 47 (24%) cats had borderline proteinuria, 147 cats had no proteinuria and two cats were excluded. One of the borderline proteinuric cats had a detectable uL-FABP concentration, whereas the other five cats with detectable uL-FABP concentrations were non-proteinuric.
Conclusion: With the current assay, the screening potential of uL-FABP as an early biomarker for feline CKD is limited as uL-FABP was rarely detected in clinically healthy elderly cats independently of the presence of either IRIS stage 1 CKD or borderline proteinuria.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9856989 | PMC |
| http://dx.doi.org/10.1002/vms3.1003 | DOI Listing |
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