Extensive road construction works recently took place in the remote eastern part of the Peruvian Cordillera Blanca, aiming at a better connection of isolated mountain communities with regional administrative centres. Here we document and characterize landslides associated with these road construction efforts in the Río Lucma catchment, Peru. We show that a total area of 321,332 m2 has been affected by landslides along the 47.1 km of roads constructed between 2015 and 2018. While landslides downslope the roads (48.2%) and complex landslides crossing the roads (46.4%) were the most frequent landslide types in relation to the position of the road; slide-type movement (60.7%) prevails over the flow-type movement (39.3%). Timewise, we found that 75.0% of landslides were observed simultaneously with road construction work, while the remaining 25.0% occurred up to seven months after the roads had been constructed. We plotted the lagged occurrence of these subsequent landslides against precipitation data, showing that 85.7% of them were observed during the wet season (November to April). We conclude that the majority of mapped landslides were directly associated with road constructions and that the road constructions also may set preconditions for landslides, which mainly occurred during the subsequent wet season.
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http://dx.doi.org/10.1590/0001-3765202220211352 | DOI Listing |
Biochemistry
January 2025
Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, Switzerland.
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View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Kobilka Institute of Innovative Drug Discovery, School of Medicine, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Road, 518172 Shenzhen, China.
Drug-induced liver injury (DILI) is a major challenge in drug development, often leading to clinical trial failures and market withdrawals due to liver toxicity. This study presents StackDILI, a computational framework designed to accelerate toxicity assessment by predicting DILI risk. StackDILI integrates multiple molecular descriptors to extract structural and physicochemical features, including the constitution, pharmacophore, MACCS, and E-state descriptors.
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Clinical Medicine Research Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Zhongshan Road 321, Nanjing, 210008, China.
Child Psychiatry Hum Dev
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Department of Psychiatry and Behavioral Health, Stony Brook University, 101 Nicolls Road, Stony Brook, NY, USA.
The diagnosis of bipolar disorder (BD) in young children has been a topic of debate, in part owing to varied interpretation of manic-like symptoms. We examined how expert academic clinicians participating in the pediatric bipolar biobank varied in their interpretation and application of Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria and diagnoses. Study co-investigators reviewed 12 standardized narratives and for each marked a visual analog scale with their confidence in the presence of manic episodes and criteria.
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Department of Gastrointestinal Surgery, Affiliated Hospital of Qingdao University, No. 16 Jiangsu Road, Qingdao, China.
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