Aim: The objective of this study was to describe the use of COVID-19-related medicines during pregnancy and their evolution between the early/late periods of the pandemic.
Methods: Pregnant women who tested positive for SARS-CoV-2 from March 2020 to July 2021 were included using the COVI-PREG registry. Exposure to the following COVID-19-related medicines was recorded: antibiotics, antivirals, hydroxychloroquine, corticosteroids, anti-interleukin-6 and immunoglobulins. We described the prevalence of medicines used, by trimester of pregnancy, maternal COVID-19 severity level and early/late period of the pandemic (before and after 1 July 2020).
Findings: We included 1964 pregnant patients who tested positive for SARS-CoV-2. Overall, 10.4% (205/1964) received at least one COVID-19-related medicine including antibiotics (8.6%; 169/1694), corticosteroids (3.2%; 62/1964), antivirals (2.0%; 39/1964), hydroxychloroquine (1.4%; 27/1964) and anti-interleukin-6 (0.3%; 5/1964). The use of at least one COVID-19-related medicine was 3.1% (12/381) in asymptomatic individuals, 4.2% (52/1233) in outpatients, 19.7% (46/233) in inpatients without oxygen, 72.1% (44/61) in those requiring standard oxygen, 95.7% (22/23) in those requiring high flow oxygen, 96.2% (25/26) in patients who required intubation and 57.1% (4/7) among patients who died. The proportion who received medicines to treat COVID-19 was higher before than after July 2020 (16.7% vs. 7.7%). Antibiotics, antivirals and hydroxychloroquine had lower rates of use during the late period.
Conclusion: Medicine use in pregnancy increased with disease severity. The trend towards increased use of corticosteroids seems to be aligned with changing guidelines. Evidence is still needed regarding the effectiveness and safety of COVID-19-related medicines in pregnancy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/bcp.15611 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Risk of Pretransplant Blood Transfusion for Primary Graft Dysfunction After Lung Transplant.
Ann Thorac Surg Short Rep
September 2024
Division of Thoracic Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Background: Primary graft dysfunction (PGD) is the leading cause of short- and long-term mortality associated with lung transplantation. The impact of pretransplantation blood transfusions for recipients is not fully elucidated.
Methods: This is a retrospective review of 206 consecutive lung transplantations performed at a single academic center (Northwestern University Feinberg School of Medicine, Chicago, IL) from January 2018 to July 2022.
Biomarkers.
Alzheimers Dement
December 2024
Federal University of Rio Grande do Sul, Brazil, Porto Alegre, RS, Brazil.
Background: The COVID-19 pandemic is a public health crisis, and its lasting consequences are not yet fully understood. Epidemiological data suggest that low- and middle-income countries, such as Brazil, will bear a considerable burden of COVID-19-related comorbidities. Individuals who have survived COVID-19 often report persistent symptoms, including neurological manifestations such as brain fog.
View Article and Find Full Text PDFThe impact of COVID-19 public health and social measures on years of potential life lost.
J Emerg Manag
January 2025
Rocky Mountain Center for Occupational and Environmental Health, University of Utah, Salt Lake City, Utah.
Background: To determine the impacts of statewide coronavirus disease 2019 (COVID-19)-related public health and social measures (PHSMs) and attempted pandemic mitigation measures on years of potential life lost (YPLL).
Methods: The "openness score" of each state during the COVID-19 pandemic was obtained using two open-source sites, the Multistate openness score and the Wallethub openness score. These scores combined various PHSMs, such as restrictions on gatherings and closing various types of businesses.
Comparison of the effectiveness of awake-prone positioning and high-flow nasal oxygen in patients with COVID-19-related acute respiratory failure between different waves.
Crit Care Sci
January 2025
Intensive Care Department, Hospital Privado de Comunidad - Mar del Plata, Argentina.
Objective: To compare the effectiveness of the awake-prone position on relevant clinical outcomes in patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen between different waves in Argentina.
Methods: This multicenter, prospective cohort study included adult patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen. The main exposure position was the awake-prone position (≥ 6 hours/day) compared to the non-prone position.
Longitudinal monitoring of sewershed resistomes in socioeconomically diverse urban neighborhoods.
Commun Med (Lond)
January 2025
Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada.
Background: Understanding factors associated with antimicrobial resistance (AMR) distribution across populations is a necessary step in planning mitigation measures. While associations between AMR and socioeconomic-status (SES), including employment and education have been increasingly recognized in low- and middle-income settings, connections are less clear in high-income countries where SES remains an important influence on other health outcomes.
Methods: We explored the relationship between SES and AMR in Calgary, Canada using spatially-resolved wastewater-based surveillance of resistomes detected by metagenomics across eight socio-economically diverse urban neighborhoods.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!