New Zealand has long been praised for the effectiveness of its COVID-19 elimination strategy. It resulted in fewer COVID-19-related deaths, better economic recovery, and less stringent policy measures within its borders compared with other OECD countries, which opted for mitigation or suppression. However, since September 2021, the rising number of infections has not been contained anymore by the contact tracing and self-isolation system in place and the government has shifted towards a policy strategy similar to suppression to manage the crisis. In this case study, we analyse the factors that led the government to switch policy and discuss why elimination became unsustainable to manage the COVID-19 epidemic in New Zealand. Results showed that the socioeconomic and political factors, along with the appearance of new variants and a delayed vaccination program, were accountable for the switch in strategy. This switch allows the country to better adapt to the evolving nature of the disease and to address the social and economic repercussions of the first year of measures. Our conclusion does not disregard elimination as an appropriate initial strategy to contain this pandemic in the absence of a vaccine or treatment, but rather suggests that borders cannot remain closed for long periods of time without creating social, economical, and political issues.
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http://dx.doi.org/10.3390/epidemiologia3010011 | DOI Listing |
Angew Chem Int Ed Engl
January 2025
University of Oxford, Department of Chemistry Chemistry Research Laboratory, Mansfield Road, OX1 3TA, Oxford, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Compounds containing quaternary stereocentres are a valuable motif in biologically active compounds. Herein we present our strategy to utilise the hydrogen borrowing manifold to access α-quaternary ketones via a tandem acceptorless dehydrogenation-cyclisation cascade. This new application of the methodology results in the formation of five- and six-membered carbocycles with a high degree of diastereoselectivity.
View Article and Find Full Text PDFBackground: Down Syndrome (DS) is the most common genetic form of intellectual disability. In recent years, there has been a significant increase in the life expectancy of individuals with DS, currently reaching the age of 60 or over. However, it has been observed that as of age 40, these individuals experience higher risk of developing dementia, and almost all of them exhibit histopathological characteristics of Alzheimer's disease (AD) in their brains.
View Article and Find Full Text PDFExpert Rev Pharmacoecon Outcomes Res
January 2025
Evaluation and Implementation Science Unit, Centre for Health Policy, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.
Introduction: Cervical cancer is almost entirely preventable by vaccination and screening. Population based vaccination and screening programs are effective and cost effective, but millions of people do not have access to these programs, causing immense suffering. The WHO Global Strategy for the elimination of cervical cancer as a public health problem calls for countries to meet ambitious vaccination, screening and treatment targets.
View Article and Find Full Text PDFBiomacromolecules
January 2025
Macromolecular Engineering Laboratory, Institute of Energy and Process Engineering, Department of Mechanical and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland.
Small molecules are frontline therapeutics for many diseases; however, they are often limited by their poor solubility. Therefore, hydrophobic small molecules are often encapsulated or prepared as pure drug nanoparticles. Navitoclax, used to eliminate senescent cells, is one such small molecule that faces challenges in translation due to its hydrophobicity and toxic side effects.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
Department of Orthopedics, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Spinal cord injury (SCI) impairs the central nervous system and induces the myelin-sheath-deterioration because of reactive oxygen species (ROS), further hindering the recovery of function. Herein, the simultaneously emergency treatment and dynamic luminescence severity assessment (SETLSA) strategy is designed for SCI based on cerium (Ce)-doped upconversion antioxidant nanoenzymes (Ce@UCNP-BCH). Ce@UCNP-BCH can not only efficiently eliminate the SCI localized ROS, but dynamically monitor the oxidative state in the SCI repair process using a ratiometric luminescence signal.
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