AI Article Synopsis
- The study investigated genetic variants and their impact on plasma uracil and dihydrouracil levels in a group of 100 healthy Indian adults.
- It identified two prevalent genetic variants, c.1906-14763G>A and c.85T>C, with most participants showing a lower DHU-to-uracil ratio due to these variants.
- Additionally, 40% of intermediate metabolizers had altered phenotypic measurements, indicating significant variations in metabolic responses among participants based on their genotypes.
Article Abstract
This study aimed to identify variants and the related but previously unexplored phenotype (plasma uracil, dihydrouracil [DHU], and the DHU-to-uracil ratio) in a healthy adult Indian population. Healthy adult volunteers (n = 100) had their uracil and DHU levels measured and were genotyped for selected variants. Among the nine variants studied, c.1906-14763G>A and c.85T>C were the most prevalent. Participants with any of the variants except for c.85T>C and c.1627A>G had a significantly lower DHU-to-uracil ratio and those with c.1905+1G>A variant had significantly increased uracil concentration compared with wild-type. Participants with five variants were identified as having altered phenotypic measures, and 40% of the intermediate metabolizers had their phenotype in the terminal population percentiles.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/pme-2022-0042 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!