AI Article Synopsis
- Oligodendrocyte progenitor cells (OPCs) develop in the brain and spinal cord and primarily differentiate into oligodendrocytes (OLs), which are crucial for myelin production.
- Recent studies highlight that both OPCs and OLs exhibit variability in their characteristics, making traditional methods like Bulk RNA-seq inadequate for understanding their diversity.
- Advanced techniques, such as single-cell sequencing (scRNA-seq) and single-cell nuclear sequencing (snRNA-seq), have been employed to analyze distinct subpopulations of OL lineage cells, enhancing our understanding of their development and relevance in various diseases.
Article Abstract
Oligodendrocyte progenitor cells (OPCs) originate in the ventricular zone (VZ) of the brain and spinal cord, and their primary function is to differentiate into oligodendrocytes (OLs). Studies have shown that OPCs and OLs are pathologically and physiologically heterogeneous. Previous transcriptome analyses used Bulk RNA-seq, which compares average gene expression in cells and does not allow for heterogeneity. In recent years, the development of single-cell sequencing (scRNA-seq) and single-cell nuclear sequencing (snRNA-seq) has allowed us to study an individual cell. In this review, sc/snRNA-seq was used to study the different subpopulations of OL lineage cells, their developmental trajectories, and their applications in related diseases. These techniques can distinguish different subpopulations of cells, and identify differentially expressed genes in particular cell types under certain conditions, such as treatment or disease. It is of great significance to the study of the occurrence, prevention, and treatment of various diseases.
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| http://dx.doi.org/10.1111/jnc.15728 | DOI Listing |
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