AI Article Synopsis
- Intracranial volume (ICV), measured through MRI or head circumference, is hereditary and linked to cognitive abilities and neurological disorders.
- A genome-wide association study identified 64 genetic variants associated with ICV, explaining about 5% of its variation and pointing to 12 key genes involved in cranial conditions.
- The study found that ICV is connected to brain region sizes and various traits, with Parkinson's disease linked to larger ICV and attention deficit hyperactivity disorder (ADHD) associated with smaller ICV.
Article Abstract
Intracranial volume, measured through magnetic resonance imaging and/or estimated from head circumference, is heritable and correlates with cognitive traits and several neurological disorders. We performed a genome-wide association study meta-analysis of intracranial volume ( = 79 174) and found 64 associating sequence variants explaining 5.0% of its variance. We used coding variation, transcript and protein levels, to uncover 12 genes likely mediating the effect of these variants, including and that affect cranial synostosis and microcephaly, respectively. Intracranial volume correlates genetically with volumes of cortical and sub-cortical regions, cognition, learning, neonatal and neurological traits. Parkinson's disease cases have greater and attention deficit hyperactivity disorder cases smaller intracranial volume than controls. Our Mendelian randomization studies indicate that intracranial volume associated variants either increase the risk of Parkinson's disease and decrease the risk of attention deficit hyperactivity disorder and neuroticism or correlate closely with a confounder.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9677475 | PMC |
| http://dx.doi.org/10.1093/braincomms/fcac271 | DOI Listing |
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