Previous studies suggest an association between celiac disease and anorexia nervosa. Research has mainly focused on children and adolescents, and studies among adults are limited. The similar clinical manifestations that characterize both diseases can complicate the diagnosis, and a thorough diagnostic workup is necessary. A focused medical history remains the cornerstone of diagnosis. A delayed diagnosis can lead to a worse quality of life and severe complications. We present the case of a 43-year-old woman with anorexia nervosa who was thereafter diagnosed with celiac disease. The later diagnosis occurred after a long period of persistent diarrhea. Based on the patient's history of autoimmune disease, celiac disease was suspected. Our case highlights the importance of additional work-up in patients with anorexia nervosa who have persistent gastrointestinal symptoms. A further investigation should be based on the medical history, clinical presentation, and laboratory findings.
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http://dx.doi.org/10.7759/cureus.30494 | DOI Listing |
Synapse
January 2025
Center for Neural Science, New York University, New York, New York, USA.
Objective: Anorexia nervosa (AN) is an eating disorder with the second highest mortality of all mental illnesses and high relapse rate, especially among adult females, yet with no accepted pharmacotherapy. A small number of studies have reported that adult females who struggled with severe and relapsing AN experienced sustained remission of the illness following ketamine infusions. Two other reports showed that 30 mg/kg IP ketamine can reduce vulnerability of adolescent mice to activity-based anorexia (ABA), an animal model of AN.
View Article and Find Full Text PDFPerit Dial Int
January 2025
Division of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Anorexia nervosa (AN) is an eating disorder characterized by restriction of energy intake leading to a significantly low body weight, and intense fear of gaining weight. Severe electrolyte changes such as hypokalemia and hypophosphatemia; and alterations in water metabolism such as hyponatremia and edema, can occur in patients with AN. Hypokalemia and chronic volume depletion may lead to acute kidney injury (AKI) and chronic kidney disease (CKD).
View Article and Find Full Text PDFPLoS One
January 2025
Professeur Honoraire au Collège de France, Paris, France.
Background: Abnormalities in body perception in patients affected by anorexia nervosa have been widely studied, but without explicit reference to their relationship to others and the social processes involved. Yet, there are a several arguments supporting impairments in interpersonal relationships in these patients. Notably, some evidence suggests that self/other distinction (SOD), the ability to distinguish one's own body, actions and mental representations from those of others could be impaired.
View Article and Find Full Text PDFEur Eat Disord Rev
January 2025
ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Denver, Colorado, USA.
Objective: Refeeding oedema, believed to result from the effects of insulin on renal sodium retention and subsequent oedema formation, typically occurs during the first 2 weeks after reintroduction of nutrition in individuals with severe malnutrition and can intensify body image distress in patients with eating disorders (EDs). Phosphate supplements have been found to increase insulin sensitivity, and it is hypothesised that they may also contribute to refeeding oedema in patients with EDs.
Method: In this retrospective cohort study of 633 patients with severe malnutrition due to anorexia nervosa (AN) or avoidant restrictive food intake disorder (ARFID), the impact of phosphate supplementation on the rate of weight gain was investigated.
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