AI Article Synopsis
- Effective drug delivery is crucial for medical treatments, and polymeric drug delivery systems (DDSs) offer advantages like protection of drugs, targeted release, and fewer side effects compared to traditional methods.
- Over the past ten years, both natural and recombinant silks have gained popularity as effective DDSs due to their unique properties, including their ability to assemble in water, carry drugs, and degrade safely.
- This review discusses the sources and design of silk-based biomaterials, emphasizing how incorporating specific sequences can enhance drug binding and improve overall delivery efficiency across various formats like films, hydrogels, sponges, and particles.
Article Abstract
Effective drug delivery is essential for the success of a medical treatment. Polymeric drug delivery systems (DDSs) are preferred over systemic administration of drugs due to their protection capacity, directed release, and reduced side effects. Among the numerous polymer sources, silks and recombinant silks have drawn significant attention over the past decade as DDSs. Native silk is produced from a variety of organisms, which are then used as sources or guides of genetic material for heterologous expression or engineered designs. Recombinant silks bear the outstanding properties of natural silk, such as processability in aqueous solution, self-assembly, drug loading capacity, drug stabilization/protection, and degradability, while incorporating specific properties beneficial for their success as DDS, such as monodispersity and tailored physicochemical properties. Moreover, the on-demand inclusion of sequences that customize the DDS for the specific application enhances efficiency. Often, inclusion of a drug into a DDS is achieved by simple mixing or diffusion and stabilized by non-specific molecular interactions; however, these interactions can be improved by the incorporation of drug-binding peptide sequences. In this review we provide an overview of native sources for silks and silk sequences, as well as the design and formulation of recombinant silk biomaterials as drug delivery systems in a variety of formats, such as films, hydrogels, porous sponges, or particles.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812964 | PMC |
| http://dx.doi.org/10.1016/j.addr.2022.114622 | DOI Listing |
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