AI Article Synopsis
- Coronary vessel development is crucial for creating effective treatments for ischemic heart conditions.
- D'Amato et al. found that BMP2 and the CXCL12/CXCR4 signaling pathway work in sequence on endocardial cells.
- This sequential activation is key for promoting coronary angiogenesis and the formation of artery structures.
Article Abstract
Understanding how coronary vessels develop is important for designing better strategies to repair ischemic hearts. In this issue of Developmental Cell, D'Amato et al. report that BMP2 and CXCL12/CXCR4 act sequentially on endocardial cells to drive coronary angiogenesis and artery morphogenesis.
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| http://dx.doi.org/10.1016/j.devcel.2022.11.001 | DOI Listing |
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