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Lectin-based phototherapy targeting cell surface glycans for pancreatic cancer. | LitMetric

AI Article Synopsis

  • Pancreatic ductal adenocarcinoma (PDAC) is difficult to treat, but a new lectin-based therapy called Lec-PT combines a PDAC-targeting lectin, rBC2LCN, with a photoabsorber, IRDye700DX, to create a targeted cancer treatment activated by near-infrared light.
  • In laboratory tests, Lec-PT demonstrated cytotoxic effects on PDAC cell lines when exposed to near-infrared light, and in animal studies, it showed significant tumor growth reduction and cell-specific targeting.
  • Lec-PT has minimal off-target toxicity when organs are shielded from the treatment light, suggesting it could effectively treat pancreatic cancer with

Article Abstract

Pancreatic ductal adenocarcinoma (PDAC) is resistant to current treatments but lectin-based therapy targeting cell surface glycans could be a promising new horizon. Here, we report a novel lectin-based phototherapy (Lec-PT) that combines the PDAC targeting ability of rBC2LCN lectin to a photoabsorber, IRDye700DX (rBC2-IR700), resulting in a novel and highly specific near-infrared, light-activated, anti-PDAC therapy. Lec-PT cytotoxicity was first verified in vitro with a human PDAC cell line, Capan-1, indicating that rBC2-IR700 is only cytotoxic upon cellular binding and exposure to near-infrared light. The therapeutic efficacy of Lec-PT was subsequently verified in vivo using cell lines and patient-derived, subcutaneous xenografting into nude mice. Significant accumulation of rBC2-IR700 occurs as early as 2 hours postintravenous administration while cytotoxicity is only achieved upon exposure to near-infrared light. Repeated treatments further slowed tumor growth. Lec-PT was also assessed for off-target toxicity in the orthotopic xenograft model. Shielding of intraperitoneal organs from near-infrared light minimized off-target toxicity. Using readily available components, Lec-PT specifically targeted pancreatic cancer with high reproducibility and on-target, inducible toxicity. Rapid clinical development of this method is promising as a new modality for treatment of pancreatic cancer.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107464PMC
http://dx.doi.org/10.1002/ijc.34362DOI Listing

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