A 58-year-old woman was admitted to hospital for deceased donor liver transplant. Her liver volume, measured by computed tomography, had reached 22,764 cm and she was bedridden with performance status 3 because of abdominal distention. The Model for End-Stage Liver Disease score was 24 with exception points. The final weight of the removed liver after cystic fluid puncture was 14 kg. The patient recovered well after transplant and was discharged on postoperative day 43 with a weight of 41 kg and performance status of 1.
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http://dx.doi.org/10.1016/j.transproceed.2022.10.033 | DOI Listing |
Alzheimers Dement
December 2024
Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Background: Enlarged perivascular spaces (ePVS) on MRI can signal impaired cerebral fluid clearance and predict dementia risk. Risk factors and biological correlates of ePVS are uncertain partially due to the lack of pathological correlation studies. Repetitive head impacts (RHI) from contact sports might represent one risk factor for ePVS, given their association with vascular pathologies and chronic traumatic encephalopathy (CTE), a neurodegenerative disease characterized by perivascular p-tau aggregates.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Icahn School of Medicine, Mount Sinai Hospital, New York, NY, USA.
Background: Adverse social exposome (indexed by national Area Deprivation Index [ADI] 80-100 or 'high ADI') is linked to structural inequities and increased risk of Alzheimer's disease neuropathology. Twenty percent of the US population resides within high ADI areas, predominantly in inner cities, tribal reservations and rural areas. The percentage of brain donors from high ADI areas within the Alzheimer's Disease Research Center (ADRC) brain bank system is unknown.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: The social exposome, all social-environmental exposures accumulated over the life course, could partially explain Alzheimer's disease and other dementias (ADRD) disparities. Measurement and linkage of life course social exposome metrics to biological samples may inform opportunities for intervention. While there is increasing emphasis on the life course social exposome in ADRD research, there is little consensus on its measurement.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: Working conditions and contexts may influence the development of Alzheimer's Disease and related dementias (ADRD), exposing individuals to modifiable risk factors across their life. Measurement of ADRD pathology at autopsy provides a gold standard outcome for evaluating the effects of lifetime exposures, but approaches to quantify ante-mortem work exposures are limited. Here we describe a new method to retrospectively capture occupational histories by systematically extracting occupational information using archival public records- i.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Icahn School of Medicine, Mount Sinai Hospital, New York, NY, USA.
Background: Adverse social exposome (indexed by high national Area Deprivation Index [ADI]) is linked to structural inequities and increased risk of clinical dementia diagnosis, yet linkage to ADRD neuropathology remains largely unknown. Early work from single site brain banks suggests a relationship, but assessment in large national cohorts is needed to increase generalizability and depth, particularly for rarer neuropathology findings.
Objective: Determine the association between adverse social exposome by ADI and ADRD neuropathology for brain donors from 21 Alzheimer's Disease Research Center (ADRC) brain banks as part of the on-going Neighborhoods Study.
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