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| http://dx.doi.org/10.2215/CJN.12491022 | DOI Listing |
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[Bardoxolone methyl alleviates acute liver injury in mice by inhibiting NLRP3 inflammasome activation].
Nan Fang Yi Ke Da Xue Xue Bao
September 2024
Anhui Provincial Key Laboratory of Immunology in Chronic Disease, Bengbu Medical University, Bengbu 233030, China.
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Mitochondrial-Derived Signaling Mediates Differentiation of Parietal Epithelial Cells into Podocytes.
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Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Renji Hospital, Shanghai Peritoneal Dialysis Research Center, Uremia Diagnosis and Treatment Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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Macrophage ILF3 promotes abdominal aortic aneurysm by inducing inflammatory imbalance in male mice.
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The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China.
Imbalance of proinflammatory and anti-inflammatory responses plays a crucial role in the progression of abdominal aortic aneurysms. ILF3, a known modulator of the innate immune response, is involved in cardiovascular diseases. This study aims to investigate the role of ILF3 in abdominal aortic aneurysm formation.
View Article and Find Full Text PDFTargeted-lung delivery of bardoxolone methyl using PECAM-1 antibody-conjugated nanostructure lipid carriers for the treatment of lung inflammation.
Biomed Pharmacother
September 2024
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China. Electronic address:
The effective treatment of acute lung injury (ALI) remains a significant challenge. Patients with ALI demonstrate an abundance of proinflammatory mediators in both bronchoalveolar lavage fluid (BALF) and circulating plasma. Bardoxolone methyl (BM) is a semi-synthetic triterpenoid derived from oleanolic acid, a natural product known for its ability to inhibit proinflammatory signaling.
View Article and Find Full Text PDFNew CDDO Arylboronate Ester Derivatives with High Selectivity and Low Toxicity.
J Med Chem
August 2024
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, China.
As an oleanolic acid derivative, CDDO-Me lacks selectivity for tumors. Based on the high reactive oxygen species (ROS) level in cancer cells, compound was selected from 17 new CDDO arylboronate ester derivatives. A preliminary study revealed that displayed the highest selectivity for cancer cells.
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