Aims: The aim of this study was to investigate the association between oncogenic alterations and programmed cell death ligand 1 (PD-L1) expression in lung adenocarcinomas, as well as the prognostic value of and/or mutations in patients treated with immunotherapy.
Methods: This study is a retrospective cohort study of 519 patients with lung adenocarcinomas analysed for mutations and PD-L1 expression. Data were collected from electronic pathology record system, next-generation sequencing system, and clinical databases. Association between mutations and PD-L1 expression was investigated, as well as survival statistics of the 65 patients treated with immunotherapy.
Results: 41% of the samples contained a mutation, predominantly together with mutations in (41%) or (10%). Higher expression of PD-L1 was seen among patients with mutations (p=0.002) and wild type (p=0.006). For patients treated with immunotherapy, there was no statistically significant difference for overall survival (OS) and progression-free survival (PFS) according to mutation status, mutation status or PD-L1 expression. The HR for concomitant mutations in and was 0.78 (95% CI 0.62 to 0.99) for OS and 0.43 (0.21 to 0.88) for PFS. Furthermore, concomitant and mutations predicted a better PFS (p=0.015) and OS (p=0.029) compared with no mutations or a single mutation in either or .
Conclusion: Mutations in together with may serve as a potential biomarker for survival benefits with immunotherapy.
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| http://dx.doi.org/10.1136/jcp-2022-208574 | DOI Listing |
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