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| http://dx.doi.org/10.1016/j.jbspin.2022.105492 | DOI Listing |
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Multi-omics characterization of the monkeypox virus infection.
Nat Commun
August 2024
Institute of Virology, Technical University of Munich, School of Medicine, Munich, Germany.
Multiple omics analyzes of Vaccinia virus (VACV) infection have defined molecular characteristics of poxvirus biology. However, little is known about the monkeypox (mpox) virus (MPXV) in humans, which has a different disease manifestation despite its high sequence similarity to VACV. Here, we perform an in-depth multi-omics analysis of the transcriptome, proteome, and phosphoproteome signatures of MPXV-infected primary human fibroblasts to gain insights into the virus-host interplay.
View Article and Find Full Text PDFReactive Arthritis After mpox Vaccination.
J Community Hosp Intern Med Perspect
January 2024
Department of Internal Medicine, MedStar Union Memorial Hospital, Baltimore, MD, USA.
Autoimmune inflammatory reaction after vaccination is a rare clinical entity. Reactive arthritis has been described after various vaccinations, but not after mpox vaccination. Here we present a case of recently diagnosed reactive arthritis after mpox vaccination that presented in the context of unrelenting fever and diarrhea complicated by migratory arthritis and anterior uveitis.
View Article and Find Full Text PDFPalisade structure in intact vaccinia virions.
mBio
February 2024
Cellular Signalling and Cytoskeletal Function Laboratory, The Francis Crick Institute, London, United Kingdom.
Vaccinia virus assembly in the cytoplasm of infected cells involves the formation of a biconcave viral core inside the maturing viral particle. The boundary of the core is defined by a pseudohexagonal palisade layer, composed of trimers projecting from an inner wall. To understand the assembly of this complex core architecture, we obtained a subnanometer structure of the palisade trimer by cryo-electron tomography and subtomogram averaging of purified intact virions.
View Article and Find Full Text PDFClassic IgA-Vasculitis With Nephrotic Range Proteinuria - Rare Presentation in an Adult.
J Community Hosp Intern Med Perspect
May 2023
Internal Medicine Department, Creighton University School of Medicine, USA.
IgA vasculitis formerly known as Henoch-Schonlein Purpura is characterized by leukocytoclastic vasculitis and IgA immune complex in small vessels of the affected organ. IgA vasculitis can involve any organ system depending upon the deposition of the IgA immune complex. IgA vasculitis is a clinical diagnosis which manifest with abdominal pain, arthralgia/arthritis, palpable purpura, and kidney involvement.
View Article and Find Full Text PDFMpox-A Rapidly Evolving Disease.
JAMA Dermatol
April 2023
Department of Dermatology, University of California, San Francisco.
Article Synopsis
- The 2022 mpox outbreak has gained global attention amidst the ongoing COVID-19 pandemic, presenting distinct challenges in diagnosis and treatment.
- Unlike COVID-19, mpox primarily shows skin symptoms that can resemble other skin conditions, especially sexually transmitted infections, making it difficult to identify.
- This Special Communication outlines the history of mpox skin symptoms from their first identification in 1970 to the current widespread outbreak across multiple countries.
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