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http://dx.doi.org/10.1073/pnas.2216092119 | DOI Listing |
Curr Top Behav Neurosci
January 2025
Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Behavioral and psychological symptoms of dementia (BPSD), such as agitation, apathy, and psychosis, are highly prevalent and have a significant impact on patients and their care partners. The neurobiology of BPSD involves a complex interplay of structural brain changes and alterations in the neurotransmitter system. Various genetic and plasma biomarkers have also been studied.
View Article and Find Full Text PDFTrop Med Infect Dis
December 2024
Laboratório de Mamíferos, Programa de Pós-Graduação em Ciências Biológicas, Departamento de Sistemática e Ecologia, Centro de Ciências Exatas e da Natureza, Universidade Federal da Paraíba, João Pessoa 58051-900, PB, Brazil.
The urbanization process has led to significant changes in the landscape, shifting the epidemiological profile of the visceral leishmaniasis (VL) in Brazil. Dogs are considered the main urban reservoir of VL, whose infections precede cases in humans. In order to understand the socio-environmental determinants associated with canine visceral leishmaniasis (CVL), we conducted a spatial analysis of CVL cases in northeastern Brazil from 2013 to 2015, georeferencing 3288 domiciled dogs.
View Article and Find Full Text PDFInorg Chem
January 2025
CNRS, University of Bordeaux, Bordeaux INP, ICMCB UMR CNRS 5026, F-33600 Pessac ,France.
The diaspore-type crystalline structure is historically well-known in mineralogy, but it has also been widely studied for various applications in the field of catalysis, electrocatalysis, and batteries. However, once two anions of similar ionic size but different electronegativity, such as F and O or more precisely OH, are combined, the knowledge of the location of these two anions is of paramount importance to understand the chemical properties in relation with the generation of hydrogen bonds. Coprecipitation and hydrothermal routes were used to prepare hydroxide-fluorides that crystallize all in an orthorhombic structure with four formula units per cell.
View Article and Find Full Text PDFSci Rep
January 2025
The Provincial Key Laboratory of Multimodal Perceiving and Intelligent Systems, Jiaxing University, Jiaxing, 314001, China.
This paper investigates the noncooperative game problems over weight-balanced digraphs with communication delays. Compared with existing noncooperative games, a class of noncooperative games that are more aligned with practical systems is discussed, where all agents have uncertain heterogeneous second-order nonlinear dynamics. Then, considering two different types of communication delays, respectively slowly-varying communication delays and fast-varying communication delays, the distributed algorithm is designed to seek the Nash equilibrium (NE).
View Article and Find Full Text PDFiScience
January 2025
Blue Brain Project, École Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech, 1202 6 Geneva, Switzerland.
We hypothesized that the heterogeneous architecture of biological neural networks provides a substrate to regulate the well-known tradeoff between robustness and efficiency, thereby allowing different subpopulations of the same network to optimize for different objectives. To distinguish between subpopulations, we developed a metric based on the mathematical theory of simplicial complexes that captures the complexity of their connectivity by contrasting its higher-order structure to a random control and confirmed its relevance in several openly available connectomes. Using a biologically detailed cortical model and an electron microscopic dataset, we showed that subpopulations with low simplicial complexity exhibit efficient activity.
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