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Olfaction in Complex Regional Pain Syndrome. | LitMetric

Olfaction in Complex Regional Pain Syndrome.

Pain Med

Centre for Healthy Ageing and Discipline of Psychology, College of Science, Health, Engineering and Education, Murdoch University, Murdoch, Western Australia, Australia.

Published: June 2023

AI Article Synopsis

  • The study investigated how patients with Complex Regional Pain Syndrome (CRPS) perceive household odors compared to healthy individuals, focusing on the intensity and pleasantness of smells.
  • Researchers used six different odorants and assessed ratings from both CRPS patients and pain-free controls, while also examining differences between the symptomatic and unaffected sides of the patients.
  • Results indicated that CRPS patients found odors to be generally less pleasant than controls, but there were no significant differences in odor intensity or unpleasantness between the painful and non-painful sides, suggesting a unique interaction between pain signals and odor perception in CRPS.

Article Abstract

Objective: Complex regional pain syndrome (CRPS) is associated with a range of sensory disturbances on the symptomatic side of the body but whether this includes olfaction is uncertain. To clarify this, the aims of this study were to compare ratings of intensity and hedonic appeal of household odorants in CRPS patients and controls, and to determine whether ratings differed between the symptomatic and contralateral sides within the sample of patients.

Methods: Six odorants (vanilla, fish sauce, vinegar, eucalyptus, almond essence and acetone) were presented sequentially in random order on cottonwool buds held in the midline approximately 1 cm from both nostrils in 37 CRPS patients and 21 pain-free controls. Each odor was rated for intensity and hedonic appeal, and participants reported whether the odor was stronger and/or smelt different on one side than the other.

Results: The odorants smelt worse for patients than controls (P < .05 for the symptomatic and contralateral sides) but neither the intensity nor the unpleasantness of the odorants was greater on the symptomatic than contralateral side in the group as-a-whole.

Conclusions: These findings suggest that the trigeminal component of olfaction interacts bilaterally with pain-sensitized circuits in the thalamus or higher cortical centers to distort odor perception in patients with CRPS. This aberrant process appears to differ from the mechanism that underlies hemilateral hyperalgesia in other sensory modalities.

Download full-text PDF

Source
http://dx.doi.org/10.1093/pm/pnac180DOI Listing

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