Degradable polyester-based scaffolds are ideal for tissue engineering applications where long-term structural integrity and mechanical support are a requisite. However, their hydrophobic and unfunctionalized surfaces restrain their tissue-mimetic quality. Instead, hyaluronan (HA) hydrogels are able to act as cell-instructive materials with the ability to recapitulate native tissue, although HA is rapidly metabolized . Taking advantage of these distinctly diverse material properties, a degradable and concurrent hybrid hydrogel material was developed that combines the short-term tissue-relevant properties of bio-orthogonal crosslinked HA with the long-term structural and mechanical support of poly(l-lactide--trimethylene carbonate) (PLATMC) scaffolds. This method rendered the formulation of transparent, minimally swelling hydrogel compartments with a desirable cell-instructive "local" elastic modulus within the scaffold matrix without impeding key material properties of PLATMC. Long-term degradability over 180 days was realized by the integral PLATMC scaffold architecture obtained through either extrusion-based 3D printing or salt-particulate leaching. Intrinsic diffusion capacity within the hydrogel elicited unaffected degradation kinetics of PLATMC , despite its autocatalytic bulk degradation characteristics displayed when 3D-printed. The effect of the processing method on the material properties of PLATMC markedly extends to its degradation characteristics, and essential uniform degradation behavior can be advanced using salt-particulate leaching. Regardless of the scaffold fabrication method, the polymer exhibited a soft and flexible nature throughout the degradation period, governed by the rubbery state of the polymer. Our results demonstrate that the physicochemical properties of the hybrid hydrogel scaffold endow it with the potential to act as a cell instructive microenvironment while not affecting key material properties of PLATMC postprocessing. Importantly, the HA hydrogel does not adversely impact the degradation behavior of PLATMC, a vital aspect in the fabrication of tissue engineering constructs. The results presented herein open new avenues for the adoption of concurrent and well-defined tissue-relevant materials exhibiting the potential to recreate microenvironments for cell encapsulation and drug delivery while providing essential structural integrity and long-term degradability.
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http://dx.doi.org/10.1016/j.mtbio.2022.100483 | DOI Listing |
Sensors (Basel)
December 2024
School of Physics and Optoelectronics, Xiangtan University, Xiangtan 411105, China.
In the case of waveguide-based devices, once they are fabricated, their optical properties are already determined and cannot be dynamically controlled, which limits their applications in practice. In this paper, an isosceles triangular-coupling structure which consists of an isosceles triangle coupled with a two-bus waveguide is proposed and researched numerically and theoretically. The coupled mode theory (CMT) is introduced to verify the correctness of the simulation results, which are based on the finite difference time domain (FDTD).
View Article and Find Full Text PDFSensors (Basel)
December 2024
Institute of Mechatronics and Information Systems, Lodz University of Technology, 90-537 Lodz, Poland.
This paper is devoted to the development of a window-type inductive current transformer (iCT) with a rated primary current equal to 400 A and two secondary windings with rated currents of 5 A and 1 A. Its novelty concerns the presentation of this process in the case of an iCT with a 0.2S accuracy class ensured not only for a sinusoidal current of a frequency of 50 Hz but also for the transformation of distorted current in the harmonic frequency range from 50 Hz to 5 kHz.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Group of Quality Assurance and Industrial Image Processing, Faculty of Mechanical Engineering, Technische Universität Ilmenau, Gustav-Kirchhoff-Platz 2, 98693 Ilmenau, Germany.
Multispectral imaging (MSI) enables the acquisition of spatial and spectral image-based information in one process. Spectral scene information can be used to determine the characteristics of materials based on reflection or absorption and thus their material compositions. This work focuses on so-called multi aperture imaging, which enables a simultaneous capture (snapshot) of spectrally selective and spatially resolved scene information.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Background/objectives: Crickets are recognized as an alternative source of chitosan. This study aimed to assess the potential of cricket-derived chitosan as a natural source to develop chitosan nanoparticles (CNPs).
Methods: Chitosan were isolated from different cricket species, including , , and .
Pharmaceutics
December 2024
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34 Curie-Skłodowskiej St., 41-819 Zabrze, Poland.
: Cancer remains one of the leading causes of death worldwide, and thus, there is a need for the development of innovative and more effective treatment strategies. The aim of the study was to evaluate two types of nanoparticles-nanospheres and micelles-obtained from PLA-based polymers to discover their potential for delivering four types of phenothiazine derivatives. : The morphology, drug-loading properties, cytocompatibility, hemolytic properties and anticancer activity were analyzed.
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