AI Article Synopsis
- The study examined the antibacterial properties of microalgae extracts from the Persian Gulf against various Gram-positive and Gram-negative bacteria to identify potential new antibacterial compounds.
- The methanolic extract demonstrated stronger antibacterial effects compared to the ethyl acetate extract, with notable effectiveness observed at a concentration of 500 mg/ml.
- Findings confirm the potential of Persian Gulf microalgae extracts as natural antimicrobials, suggesting their use in pharmaceutical applications for treating bacterial infections.
Article Abstract
Background: We aimed to investigate the antibacterial activity of Persian Gulf microalgae extracts on some Gram-positive and negative bacterial species in order to find new compounds with antibacterial activity.
Methods: After sampling microalgae from December 2020 to April 2021 from the northernmost part of Qeshm Island in Persian Gulf, the antibacterial activity of methanolic and ethyl acetate extract of microalgae were tested in three concentrations of 125, 250, and 500 mg/ml on Gram-positive bacteria including , , and Gram-negative bacteria including and by disk-diffusion assay and the results were compared with two standard antibiotics including ciprofloxacin and streptomycin. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were assessed spectrophotometrically using microplate and enzyme-linked immunosorbent assay (ELISA) reader.
Results: Methanolic and ethyl acetate extracts had antibacterial effects against Gram-positive and negative bacteria. Compared to ethyl acetate extract, the methanolic extract showed stronger effects on both Gram-positive and negative bacteria. The most antibacterial effect was related to methanolic extract with a concentration of 500 mg/ml on by 14.6 mm inhibition zone. Evidence from MIC also confirmed that the lowest MIC was belonged to methanolic extract by 0.75 mg/ml against . Interestingly, both of these extracts showed more antibacterial activity on Gram-positive bacteria than Gram-negative bacteria.
Conclusion: The investigation proved the efficacy of microalgae extracts isolated from Persian Gulf as natural antimicrobials and suggested the possibility of employing them in medicines as antimicrobial agents.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643229 | PMC |
| http://dx.doi.org/10.18502/ijph.v51i5.9428 | DOI Listing |
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