AI Article Synopsis
- - The study investigates the benefits of a new herbal formulation (HACBF) on reducing oxidative stress and improving cognitive function, which are critical in combating aging and neurodegenerative diseases.
- - HACBF was shown to lower aging biomarkers and enhance the activity of antioxidant enzymes, with effects comparable to common Alzheimer’s and Parkinson’s medications like donepezil and L-Dopa.
- - Molecular analysis indicated that HACBF positively influences neurotransmitter levels and gene expression related to healthy aging, suggesting it could be a valuable resource for cognitive enhancement, particularly during the ongoing COVID-19 pandemic.
Article Abstract
Unlabelled: The positive effect of herbal supplements on aging and age-related disorders has led to the evolution of natural curatives for remedial neurodegenerative diseases in humans. The advancement in aging is exceedingly linked to oxidative stress. Enhanced oxidative stress interrupts health of humans in various ways, necessitating to find stress alleviating herbal resources. Currently, minimal scientifically validated health and cognitive booster resources are available. Therefore, we explored the impact of plant extracts in different combinations on oxidative stress, life span and cognition using the multicellular transgenic humanized , and further validated the same in , besides testing their safety and toxicity. In our investigations, the final product-the HACBF (healthy ageing cognitive booster formulation) thus developed was found to reduce major aging biomarkers like lipofuscin, protein carbonyl, lipid levels and enhanced activity of antioxidant enzymes. Further confirmation was done using transgenic worms and RT-PCR. The cognitive boosting activities analyzed in and model system were found to be at par with donepezil and L-dopa, the two drugs which are commonly used to treat Parkinson's and Alzheimer's diseases. In the transgenic model system, the HACBF exhibited reduced aggregation of misfolded disease proteins α-synuclein and increased the health of nicotinic acetylcholine receptor, levels of Acetylcholine and Dopamine contents respectively, the major neurotransmitters responsible for memory, language, learning behavior and movement. Molecular studies clearly indicate that HACBF upregulated major genes responsible for healthy aging and cognitive booster activities in and as well as in . As such, the present herbal product thus developed may be quite useful for healthy aging and cognitive boosting activities, and more so during this covid-19 pandemic.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13237-022-00407-1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649024 | PMC |
| http://dx.doi.org/10.1007/s13237-022-00407-1 | DOI Listing |
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