Francisella tularensis is a re-emerging organism causing more significant outbreaks of tularemia and fear of bioterrorism. It can be challenging to recognize tularemia due to its variable presentation, especially in low-incidence areas. Physicians must be mindful of this life-threatening infectious disease and consider it a differential diagnosis in patients with fever of unknown origin. We encountered a case of pulmonary tularemia with a unique presentation of severe headache and fever.
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| http://dx.doi.org/10.7759/cureus.30379 | DOI Listing |
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Non-vaccinal prophylaxis of tularemia.
Front Microbiol
November 2024
Centre Hospitalier Universitaire Grenoble Alpes, Centre National de Référence Francisella Tularensis, , Grenoble, France.
Tularemia is a re-emerging zoonosis in many endemic countries. It is caused by , a gram-negative bacterium and biological threat agent. Humans are infected from the wild animal reservoir, the environmental reservoir or by the bite of arthropod vectors.
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Department of Thorax Surgery, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
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- * A 51-year-old male patient presented symptoms including fever, cough, and chest pain, leading to hospitalization and further medical investigation.
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Acute Hemophagocytic Lymphohistiocytosis Due to Tularemia.
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Internal Medicine/Infectious Diseases, University of Missouri Healthcare, Columbia, USA.
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Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), Str. Privata Campeggi, 59, Pavia 27100, Italy.
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Laboratory of Mucosal Pathogens and Cellular Immunology, Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland, USA.
Unlabelled: Traditionally, successful vaccines rely on specific adaptive immunity by activating lymphocytes with an attenuated pathogen, or pathogen subunit, to elicit heightened responses upon subsequent exposures. However, recent work with and other pathogens has identified a role for "trained" monocytes in protection through memory-like but non-specific immunity. Here, we used an co-culture approach to study the potential role of trained macrophages, including lung alveolar macrophages, in immune responses to the Live Vaccine Strain (LVS) of is an intracellular bacterium that replicates within mammalian macrophages and causes respiratory as well as systemic disease.
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