The ongoing COVID-19 pandemic has caused the death of millions of people, and PCR testing is widely used as the gold standard method to detect the infections to restrict the outbreak. Through the interviews conducted with people from the field in South Korea, the UK, and Turkey, we have found that there are numerous testing strategies worldwide. Those testing strategies include drive-through and home delivery testing capabilities, local test sites, and mobile test centers. Our primary motivation is to propose a generic model based on the best practices in the UK and South Korea. Also, we aim to present a case study on Turkey for the implementation of vital procedures and increase their availability. This paper represents a study on how to construct a temporary testing logistics system during the initial phases of pandemics to increase the availability of PCR testing with the primary objective of maximizing total sample collection. The design also considers minimizing the maximum walking distance to increase the convenience of sample collection for the people living in the neighborhoods. The proposed system consists of temporary testing centers and a central laboratory. Temporary testing centers perform direct tours to the potential areas to collect samples and bring the collected sample to the designated central laboratories located at central hospitals. Moreover, to represent the non-linear inheritance of the pandemic progress within a population, we consider diminishing sample potentials over time and coverage. This new problem is defined as an extension of the Selective Vehicle Routing Problem and Covering Tour Problem. We propose a mathematical model and four two-stage math-heuristic algorithms to determine the location and routing of the temporary testing centers and their lengths of stay at each visited location. The performances of the proposed solution methodologies are tested on two data sets. The first set is constructed by the confirmed cases of the districts of Seoul, Korea, and by the interview of health personnel of H+ Yangji Hospital COVID-19 semi-mobile booth application, and the second set is constructed by 99 hospital/health centers from distinct neighborhoods of 22 districts of Istanbul, Turkey. The Pareto set of optimum solutions is generated based on total sample collection and maximum walking distance. Finally, sensitivity analyses on some design parameters are conducted.
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http://dx.doi.org/10.1016/j.trc.2022.103954 | DOI Listing |
Acta Med Philipp
November 2024
Division of Thoracic, Cardiac and Vascular Surgery, Department of Surgery, College of Medicine and Philippine General Hospital, University of the Philippines Manila.
Objective: To describe the treatment outcomes of patients who underwent Percutaneous Transluminal Angioplasty (PTA) for Central Vein Occlusive Disease (CVOD) in end-stage kidney disease and determine the association between patient profile and treatment outcomes.
Methods: A single-institution, retrospective review of patients aged 18 and above with end-stage kidney disease who underwent PTA for CVOD in the University of the Philippines - Philippine General Hospital (UP-PGH) from January 1, 2013, to December 31, 2022, was performed. These patients' demographic and clinical profiles were evaluated using means, frequencies, and percentages.
Int J Clin Oncol
January 2025
Department of Obstetrics and Gynecology, Iwate Medical University School of Medicine, 2-1-1, Idaidori, Yahaba, Iwate, 028-3695, Japan.
Background: The quality of life (QOL) of ovarian cancer patients is often impaired by refractory ascites. Cell-free and concentrated ascites reinfusion therapy (CART) is a palliative treatment for refractory ascites, but adverse events, such as fever, are problematic. Several cytokines have been suggested to be responsible for the adverse events, but they have not been investigated in detail.
View Article and Find Full Text PDFPLoS One
January 2025
Department and Faculty of Nursing and Physiotherapy, University of Lleida, Lleida, Spain.
Clin Rev Allergy Immunol
December 2024
Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Olfactory dysfunction (OD) can have serious consequences as it hinders individuals from detecting important warning signals like smoke, spoiled food, and gas leaks. This can significantly impact their nutritional status, eating satisfaction, and overall quality of life. Allergic rhinitis (AR) is a common disease that greatly affects the quality of life and can lead to a decrease, distortion, or complete loss of olfactory ability.
View Article and Find Full Text PDFACS Omega
December 2024
Department of Polymer Chemistry and Technology, Kaunas University of Technology, Radvilenu Rd. 19, 50254 Kaunas, Lithuania.
In this study, for the first time, biobased photopolymers were synthesized from phloroglucinol tris epoxy with and without different comonomers, phloroglucinol, 1,4:3,6-dianhydro-D-sorbitol, and 1,4-cyclohexanedimethanol. The rheological, thermal, mechanical, shape-memory, and antimicrobial properties of photopolymers were investigated. The addition of comonomers reduced the photocuring rate (gel time increased from 325 s to 434-861 s) and rigidity (storage modulus decreased from 330.
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