METTL16 regulates mA methylation on chronic hepatitis B associated gene HLA-DPB1 involved in liver fibrosis.

The role of genetic factors in the occurrence and progression of CHB (CHB) is still not fully explored. In recent years, genome-wide association studies on CHB patients have demonstrated that a large number of CHB-associated single nucleotide polymorphisms exist in the gene intron, which may regulate expression at the transcriptional level. Modification of RNA mA methylation is one of the key mechanisms regulating gene expression. Here we show that , an mA regulator involved in mRNA intron splicing, is differentially expressed in CHB the tissue of patients who has definite diagnosis of mild and severe fibrosis. At the same time, there are also significant differences in the expression of CHB-associated genes such as and . The expression of is related to . Furthermore, analyses of RNA binding of METTL16 and show that the silencing of in astrocytes downregulates mA and expression of HLA-DPB1. In conclusion, participates in the progression of CHB fibrosis by regulating the mA level and expression of HLA-DPB1.