Unfortunately, the COVID-19 outbreak has been accompanied by the spread of rumors and depressing news. Herein, we develop a dynamic nested optimal control model of COVID-19 and its rumor outbreaks. The model aims to curb the epidemics by reducing the number of individuals infected with COVID-19 and reducing the number of rumor-spreaders while minimizing the cost associated with the control interventions. We use the modified approximation Karush-Kuhn-Tucker conditions with the Hamiltonian function to simplify the model before solving it using a genetic algorithm. The present model highlights three prevention measures that affect COVID-19 and its rumor outbreaks. One represents the interventions to curb the COVID-19 pandemic. The other two represent interventions to increase awareness, disseminate the correct information, and impose penalties on the spreaders of false rumors. The results emphasize the importance of interventions in curbing the spread of the COVID-19 pandemic and its associated rumor problems alike.
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http://dx.doi.org/10.1016/j.patcog.2022.109186 | DOI Listing |
Biometrics
January 2025
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC H3A 1G1, Canada.
Effect modification occurs when the impact of the treatment on an outcome varies based on the levels of other covariates known as effect modifiers. Modeling these effect differences is important for etiological goals and for purposes of optimizing treatment. Structural nested mean models (SNMMs) are useful causal models for estimating the potentially heterogeneous effect of a time-varying exposure on the mean of an outcome in the presence of time-varying confounding.
View Article and Find Full Text PDFNPJ Digit Med
January 2025
Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
Intensive longitudinal sampling enhances subjective data collection by capturing real-time, dynamic inputs in natural settings, complementing traditional methods. This study evaluates the feasibility of using daily self-reported app data to assess clinical improvement among tinnitus patients undergoing treatment. App data from a multi-center randomized clinical trial were analysed using time-series feature extraction and nested cross-validated ordinal regression with elastic net regulation to predict clinical improvement based on the Clinical Global Impression-Improvement scale (CGI-I).
View Article and Find Full Text PDFSci Rep
January 2025
Department of Radiation Oncology, Henry Ford Hospital, Detroit, USA.
Best current practice in the analysis of dynamic contrast enhanced (DCE)-MRI is to employ a voxel-by-voxel model selection from a hierarchy of nested models. This nested model selection (NMS) assumes that the observed time-trace of contrast-agent (CA) concentration within a voxel, corresponds to a singular physiologically nested model. However, admixtures of different models may exist within a voxel's CA time-trace.
View Article and Find Full Text PDFJ Cell Biol
March 2025
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL) , Heidelberg, Germany.
How cells establish the interphase genome organization after mitosis is incompletely understood. Using quantitative and super-resolution microscopy, we show that the transition from a Condensin to a Cohesin-based genome organization occurs dynamically over 2 h. While a significant fraction of Condensins remains chromatin-bound until early G1, Cohesin-STAG1 and its boundary factor CTCF are rapidly imported into daughter nuclei in telophase, immediately bind chromosomes as individual complexes, and are sufficient to build the first interphase TAD structures.
View Article and Find Full Text PDFAcc Chem Res
January 2025
Laboratory for Chemistry and Life Science (CLS), Institute of Integrated Research, Institute of Science Tokyo, 4259 Nagatsuta, Midori-ku, Yokohama 226-8501, Japan.
ConspectusThe design of properties and functions of molecular assemblies requires not only a proper choice of building blocks but also control over their packing arrangements. A highly versatile unit in this context is a particular type of triptycene with substituents at the 1,8,13-positions, called tripodal triptycene, which offers predictable molecular packing and multiple functionalization sites, both at the opposite 4,5,16- or 10 (bridgehead)-positions. These triptycene building blocks are capable of two-dimensional (2D) nested hexagonal packing, leading to the formation of 2D sheets, which undergo one-dimensional (1D) stacking into well-defined "2D+1D" structures.
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