AI Article Synopsis
- - Acute lymphoblastic leukemia (ALL) is the most common cancer in children, making up 25-30% of all childhood cancers.
- - While treatment has improved thanks to chemotherapy, some patients still face serious side effects, particularly from L-Asparaginase, a key drug in treating ALL.
- - There has been a notable rise in cases of acute pancreatitis in children with ALL after receiving L-Asparaginase, illustrating the need for awareness of its potential risks.
Article Abstract
Acute lymphoblastic leukemia (ALL) is the most frequent malignancy in children,representing 25-30% of all childhood malignancies. Although treatment outcome has improved owing to advances in chemotherapy, there is still a group of patients who experience severe adverse events. L-Asparaginase is an effective antineoplastic agent used in chemotherapy of ALL. Despite its indisputable indication, it can cause various adverse effects, including acute pancreatitis (AP). Recently, an increase in the number of pediatric AP cases following L-Asparaginase in Acute Lymphoblastic Leukemia been reported. We presented a case of acute pancreatitis in children with ALL induced by administration of L-ASPA preparations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668613 | PMC |
| http://dx.doi.org/10.1016/j.lrr.2022.100357 | DOI Listing |
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