AI Article Synopsis
- PNS is a rare neurological syndrome linked to cystitis glandularis (CG) or bladder tumors, with only about 21 reported cases so far.
- Advanced cognitive impairment, including memory deficits and abnormal behavior, was the primary clinical symptom in the reported case, along with physical issues like vomiting and urinary incontinence.
- The diagnosis confirmed CG through imaging and pathology, and successful resection of CG led to the patient’s recovery, emphasizing the need for proper diagnosis and treatment of underlying causes.
Article Abstract
Background: Paraneoplastic neurological syndrome (PNS) is an unusual event. PNS caused by cystitis glandularis (CG) or a bladder tumor is extremely rare; hence, missed diagnosis or misdiagnosis can easily occur. To date, approximately 21 cases have been reported in PubMed.
Case Summary: We report a case of PNS caused by CG and describe the clinical and imaging features. The main clinical feature was advanced cognitive impairment, and early clinical features were memory impairment, decreased computational ability, and abnormal behavior. Later clinical features were dementia, vomiting, inability to eat and walk, urinary incontinence, and hematuria. Imaging features on cranial magnetic resonance imaging were diffuse white matter lesions. Paraneoplastic tumor markers were normal. A total abdominal computed tomography scan showed multiple thickened areas on the bladder wall with local prominence. Cystoscopy revealed a volcanic protuberance on the posterior wall of the bladder with a diameter of 6 cm and no pedicle. The postoperative pathological diagnosis was CG. The patient recovered well following resection of CG. PNS cases caused by previous bladder tumors can be retrieved from PubMed to describe the clinical signs and prognosis of PNS.
Conclusion: The main clinical feature of PNS caused by CG was dementia, and the imaging features were diffuse cerebral white matter lesions. Resection of CG lesions is the fundamental treatment for PNS induced by CG. This case highlights the importance of etiological treatment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669863 | PMC |
| http://dx.doi.org/10.12998/wjcc.v10.i32.11827 | DOI Listing |
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