Minimal change disease caused by polycythemia vera: A case report.

World J Clin Cases

Department of Nephrology, Shuguang Hospital Affiliated to the Shanghai University of Traditional Chinese Medicine, TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Key Laboratory of Liver and Kidney Diseases (Shanghai University of Traditional Chinese Medicine), Ministry of Education, Shanghai Key Laboratory of Traditional Chinese Clinical Medicine (20DZ2272200), Shanghai 201203, China.

Published: November 2022

Background: Polycythemia vera (PV), often attributed to the JAK2 V617F mutation, is characterized by enhanced red blood cell counts in the peripheral blood. PV-associated renal disease is clinically rare; to date, there have been reports of other chronic kidney diseases related to PV, but no reports on PV-associated minimal change disease.

Case Summary: A 37-year-old man presented with proteinuria and high red blood cell count on January 4, 2021. The patient underwent bone marrow and renal biopsies, then was subsequently diagnosed with PV and minimal change in disease. Hydroxyurea was administered and proteinuria remission was achieved. The patient's last visit was on April 14, 2022.

Conclusion: We inferred that there may be a causal relationship between PV and minimal change disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9669836PMC
http://dx.doi.org/10.12998/wjcc.v10.i32.11993DOI Listing

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