t(4;11) translocation in hyperdiploid adult acute myeloid leukemia: A case report.

Background: gene rearrangement is a common genetic abnormality of acute myeloid leukemia (AML), which predicts poor prognosis and is important in clinical diagnosis. rearrangement involves many chromosomes, among which, t(4;11) translocation is rare in AML. The present case was t(4;11) AML, accompanied by a hyperdiploid karyotype. Such cases have not been reported previously.

Case Summary: An adult male with self-reported symptoms of fatigue, febrility and hyperleukocytosis was diagnosed with AML by morphology and confirmed by immunophenotype analysis. Uncommonly, chromosomal and fluorescence hybridization (FISH) analysis showed a hyperdiploid karyotype with t(4;11) translocation and rearrangement, and a negative - fusion gene result. The patient died of respiratory and circulatory failure 5 days after diagnosis.

Conclusion: t(4;11) AML with hyperdiploid karyotype has not been reported. In this case, t(4;11) was only detected by karyotype analysis and FISH, suggesting their importance in rearrangement detection.