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Article Synopsis
  • Cardiac resynchronization therapy (CRT) is effective for treating heart failure but is under-researched in patients with common comorbidities like atrial fibrillation (AF).
  • The SMART registry enrolled 2035 patients to assess CRT response based on clinical outcomes over 12 months, focusing on factors like all-cause mortality, hospitalizations, and quality of life.
  • Results showed 58.9% of patients improved, but factors like age, AF, and diabetes were linked to lower CRT responsiveness, with patients having AF experiencing higher rates of hospitalizations and mortality compared to those in normal rhythm.
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The Best of Both Worlds: Intracoronary Imaging and Physiology, Together in Perfect Harmony?

JACC Cardiovasc Interv

November 2024

West of Scotland Regional Heart & Lung Centre, Golden Jubilee National Hospital, Glasgow, United Kingdom. Electronic address:

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Dysregulated long non-coding RNA (lncRNA) expression is linked to various cancers and may be influenced by oncogenic Epstein-Barr virus (EBV) infection, a known and detectable risk factor in oral squamous cell carcinoma (OSCC) patients. However, research on the oncogenic role of EBV-induced lncRNAs in OSCC is limited. To identify lncRNA-associated EBV infection and OSCC carcinogenesis, the differential expression of RNA-seq datasets from paired normal adjacent and OSCC tissues, and microarray data from EBV-negative and EBV-positive SCC25 cells, were identified and selected, respectively, for interaction, functional analysis, and CCK-8 cell proliferation, wound healing, and invasion Transwell assays.

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Despite the increasing importance of the condition of post-stroke cognitive impairment (PSCI), the current therapy efficacy is limited. Since oxidative stress and inflammation are targeted in anti-stroke therapy, we aimed to assess the protective effect against PSI of an orodispersible film loaded with silkworm pupae hydrolysate and a combined extract of holy basil and ginger (JP1), which show antioxidant, and anti-inflammation effects. Male Wistar rats (200-250 g) were administered JP1 at doses of 1, 10, and 100 mg/kg BW 45 min before a 6 h immobilization stress exposure for 14 days.

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