AI Article Synopsis
- Aneurysmal subarachnoid hemorrhage (aSAH)
- leads to serious complications and high rates of disability and death, with delayed cerebral ischemia (DCI) often occurring without visible vasospasm.
- A study involving 133 aSAH patients
- found that higher levels of lactate and glucose in cerebrospinal fluid (CSF) measured shortly after the hemorrhage were strong indicators of neurological decline and poor recovery after 3 months.
- Monitoring CSF lactate and glucose
- could help predict worsening neurological conditions after aSAH, highlighting the need for future research with larger patient groups to confirm these findings and improve treatment strategies.
Article Abstract
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a complex neurovascular syndrome with profound systemic effects associated with high rates of disability and mortality. Delayed cerebral ischemia (DCI), which encompasses all neurobiological events occurring in the subacute-late stage after aSAH, has a complex pathogenesis and can occur in the absence of instrumental vasospasm. Our aim was to assess the correlation between cerebrospinal fluid (CSF) lactate and glucose levels measured on the second or third day after aSAH with clinical deterioration caused by DCI and with 3-month functional outcome.
Methods: This prospective study included all aSAH patients admitted between January 2020 and December 2021 who underwent external ventricular drain placement and CSF lactate and glucose measurement.
Results: Among 133 aSAH patients, 48 had an external ventricular drain placed and early CSF lactate and glucose assessment. Independent predictors of symptomatic DCI were World Federation of Neurosurgical Societies grade IV-V (adjusted odds ratio [aOR] 25.8, 95% confidence interval [CI] 2.9-649.2, P = 0.012), elevated CSF glucose (aOR 28.8, 95% CI 3.3-775.2, P = 0.010), and elevated CSF lactate (aOR 14.7, 95% CI 1.9-205.7, P = 0.018). The only independent predictor of 3-month functional outcome was occurrence of symptomatic DCI (aOR 0.02, 95% CI 0.0-0.2, P = 0.01).
Conclusions: Elevated CSF lactate and glucose levels in the first 3 days following aSAH were independent predictors of subsequent DCI-related neurological impairment; the presence of instrumental vasospasm was not significantly correlated with DCI after multivariate adjustment. CSF lactate and glucose monitoring may represent a point-of-care test, which could potentially improve prediction of subacute neurological worsening and guide therapeutic choices. Further research with larger prospective cohorts is warranted.
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Source |
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| http://dx.doi.org/10.1016/j.wneu.2022.11.068 | DOI Listing |
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