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Identification of potent schistosomicidal compounds predicted as type II-kinase inhibitors against c-Jun N-terminal kinase SMJNK.
Front Parasitol
April 2024
Institut für Parasitologie, Biomedizinisches Forschungszentrum Seltersberg (BFS), Justus Liebig Universitaet Giessen, Giessen, Germany.
Introduction: Schistosomiasis has for many years relied on a single drug, praziquantel (PZQ) for treatment of the disease. Immense efforts have been invested in the discovery of protein kinase (PK) inhibitors; however, given that the majority of PKs are still not targeted by an inhibitor with a useful level of selectivity, there is a compelling need to expand the chemical space available for synthesizing new, potent, and selective PK inhibitors. Small-molecule inhibitors targeting the ATP pocket of the catalytic domain of PKs have the potential to become drugs devoid of (major) side effects, particularly if they bind selectively.
View Article and Find Full Text PDFAn examination of immersive journalism by bibliometric analysis from 1999 to 2023.
Heliyon
July 2024
Faculty of Communication, Department of Public Relations and Publicity, Akdeniz University, Antalya, Turkey.
Immersive journalism is an innovative storytelling approach that aims to enable the audience to experience the event or situation in the news using virtual reality, unlike traditional news narration. In this study, the literature related to the subject was searched using the keywords Immersive Journalism, 360-Degree Video, Narrative journalism, Newsgame, VR Storytelling through the Web of Science database and a data set was created from 955 publications between 1999 and 2023. No filter was applied to the studies in the data set of the study and articles, books, and early access publications as well as book chapters, editorial materials or conference proceedings in the Web of Science database were included in the study.
View Article and Find Full Text PDFVirtual reality therapy combined with physiological monitoring provides effective treatment, with objective metrics, for post-traumatic stress disorder.
Expert Rev Med Devices
January 2025
Virtual Reality Medical Center, Interactive Media Institute, San Diego, USA.
Discovering potential ERK1 inhibitors from natural products for therapeutic targeting of Alzheimer's disease.
J Alzheimers Dis
January 2025
Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
Background: Extracellular signal-regulated kinase 1 (ERK1) belongs to mitogen-activated protein kinases, which are essential for memory formation, cognitive function, and synaptic plasticity. During Alzheimer's disease (AD), ERK1 phosphorylates tau at 15 phosphorylation sites, leading to the formation of neurofibrillary tangles. The overactivation of ERK1 in microglia promotes the release of pro-inflammatory cytokines, which results in neuroinflammation.
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