AI Article Synopsis
- This study focuses on developing core outcome sets (COSs) for musculoskeletal conditions to ensure standardized outcomes in clinical trials and research.
- It will identify common core domains from existing musculoskeletal COSs and assess their development quality using established standards.
- The review involves a systematic analysis of various databases, aiming to summarize and present core domains that could guide future COS development for musculoskeletal conditions.
Article Abstract
Background: Core outcome sets (COSs) aim to reduce outcome heterogeneity in clinical practice and research by suggesting a minimum number of agreed-upon outcomes in clinical trials. Most COSs in the musculoskeletal field are developed for specific conditions. We propose that there are likely to be common core domains within existing musculoskeletal COSs that may be used as a starting point in the development of future COSs. We aim to identify common core domains from existing COSs and to facilitate the development of new COSs for musculoskeletal conditions. As a secondary aim, we will assess the development quality of these COSs.
Methods: A systematic review including musculoskeletal COSs. We will search Core Outcome Measures in Effectiveness Trials (COMET) database, MEDLINE, EMBASE, Scopus, Cochrane Methodology Register and International Consortium for Health Outcome Measurement (ICHOM). Studies will be included if related to the development of a COS in adults with musculoskeletal conditions and for any type of intervention. Quality will be assessed using the Core Outcome Set-Standards for Development (COS-STAD) recommendations. Data extracted will include scope of the COS, health condition, interventions and outcome domains. Primary outcomes will be all core domains recommended within each COS. We define a common core outcome domain as one present in at least 67% of all COSs. All findings will be summarized and presented using descriptive statistics.
Discussion: This systematic review of COSs will describe the core domains recommended within each musculoskeletal COS. Common domains found may be used in the initial stages of development of future musculoskeletal COSs.
Systematic Review Registration: PROSPERO CRD42021239141.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675955 | PMC |
| http://dx.doi.org/10.1186/s13643-022-02120-1 | DOI Listing |
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