AI Article Synopsis
- Photo-mediated Ultrasound Therapy (PUT) is a new technique that uses lower energy to selectively destroy blood vessels compared to traditional laser and ultrasound treatments.
- A high-speed PUT system was developed using a 50-kHz pulsed laser, reducing treatment time by 20 times.
- Integrating PUT with optical coherence tomography angiography (OCTA) allows for real-time monitoring and individualized treatment strategies, validated through experiments on rabbits.
Article Abstract
Photo-mediated Ultrasound Therapy (PUT), as a new anti-vascular technique, can promote cavitation activity to selectively destruct blood vessels with a significantly lower amount of energy when compared to energy level required by other laser and ultrasound treatment therapies individually. Here, we report the development of a high speed PUT system based on a 50-kHz pulsed laser to achieve faster treatment, decreasing the treatment time by a factor of 20. Furthermore, we integrated it with optical coherence tomography angiography (OCTA) for real time monitoring. The feasibility of the proposed OCTA-guided PUT was validated through in vivo rabbit experiments. The addition of OCTA to PUT allows for quantitative prescreening and real time monitoring of treatment response, thereby enabling implementation of individualized treatment strategies.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9675827 | PMC |
| http://dx.doi.org/10.1038/s41598-022-23188-8 | DOI Listing |
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