A generalized framework of feature learning enhanced convolutional neural network for pathology-image-oriented cancer diagnosis.

In this paper, a feature learning enhanced convolutional neural network (FLE-CNN) is proposed for cancer detection from histopathology images. To build a highly generalized computer-aided diagnosis (CAD) system, an information refinement unit employing depth- and point-wise convolutions is meticulously designed, where a dual-domain attention mechanism is adopted to focus primarily on the important areas. By deploying a residual fusion unit, context information is further integrated to extract highly discriminative features with strong representation ability. Experimental results demonstrate the merits of the proposed FLE-CNN in terms of feature extraction, which has achieved average sensitivity, specificity, precision, accuracy and F1 score of 0.9992, 0.9998, 0.9992, 0.9997 and 0.9992 in a five-class cancer detection task, and in comparison to some other advanced deep learning models, above indicators have been improved by 1.23%, 0.31%, 1.24%, 0.5% and 1.26%, respectively. Moreover, the proposed FLE-CNN provides satisfactory results in three important diagnosis, which further validates that FLE-CNN is a competitive CAD model with high generalization ability.